Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Kaufmann, S; Mischinger, J; Amend, B; Rausch, S; Adam, M; Scharpf, M; Fend, F; Kramer, U; Notohamiprodjo, M; Nikolaou, K; Stenzl, A; Bedke, J; Kruck, S.
First report of robot-assisted transperineal fusion versus off-target biopsy in patients undergoing repeat prostate biopsy.
World J Urol. 2017; 35(7):1023-1029
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Mischinger Johannes

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

To clarify the value of targeted versus off-target biopsies in men with a suspicion of prostate cancer (PC) and a visible lesion in multi-parametric magnetic resonance imaging (mpMRI) using transperineal robot-assisted biopsy. Fifty-five consecutive men with one non-palpable suspicious lesion in mpMRI after negative 12-core transrectal ultrasound-guided biopsy were enrolled in 2014-2015. Lesions were scored using the Prostate Imaging Reporting and Data System. A robot-assisted system was utilized to collect four robot-assisted targeted transperineal biopsy cores (RA-TB) within the lesion using mpMRI-TRUS elastic fusion. Untargeted transperineal 14-core biopsy was performed only outside the lesion (RA-UB). Histological grade was compared in biopsies and available prostatectomy specimens. Overall, 34 of 55 patients (62%) were diagnosed with PC based on biopsy. 85% of cancers were clinically significant PC (csPC) defined as GS ≥ 7. 85% of biopsy-proven cancers were detected with RA-TB alone. RA-UB identified only one additional patient with csPC and lead to upgrading in five biopsy cases (14.7%). Pathological evaluation of 14 prostatectomy specimens showed upgrading in 2 patients (14.3%), while all other patients were correctly classified by RA-TB without need of additional RA-UB. Mean procedure duration was 43 (±6) min, and only minor complications according to Clavien-Dindo were recorded during 30-day follow-up. This is the first report of transperineal robot-assisted elastic mpMRI-TRUS fusion biopsy. RA-TB of positive MR lesions enabled reliable detection of csPC, while RA-UB in MRI-negative regions is of minor importance.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Humans -
Image-Guided Biopsy - instrumentation
Image-Guided Biopsy - methods
Imaging, Three-Dimensional - methods
Magnetic Resonance Imaging - instrumentation
Magnetic Resonance Imaging - methods
Male -
Middle Aged -
Neoplasm Grading -
Prostate - diagnostic imaging
Prostate - pathology
Prostatectomy - methods
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - pathology
Reproducibility of Results -
Robotics - methods
Ultrasonography, Interventional - instrumentation
Ultrasonography, Interventional - methods

Find related publications in this database (Keywords)
Prostate cancer
3D imaging
MR-guided interventional procedures
© Med Uni Graz Impressum