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Glatz, W; Steinwender, G; Tarmann, L; Malle, EM; Schörkhuber, M; Wackernagel, W; Petrovski, G; Wedrich, A; Ivastinovic, D.
Vitreous hyper-reflective dots in pseudophakic cystoid macular edema assessed with optical coherence tomography.
PLoS One. 2017; 12(12):e0189194-e0189194 Doi: 10.1371/journal.pone.0189194 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Glatz Wilfried Maximilian
Ivastinovic Domagoj
Co-Autor*innen der Med Uni Graz
Glatz Marlene
Malle Eva Maria Birgit
Steinwender Gernot
Vajda Lisa
Wackernagel Werner
Wedrich Andreas

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This study compares the presence of vitreous hyper-reflective dots (VHDs) detected with optical coherence tomography (OCT) between eyes with pseudophakic cystoid macular edema (CME) and those with no CME after cataract surgery. In addition, we evaluated the impact of VHDs on the responsiveness of pseudophakic CME to cortisone treatment. Department of Ophthalmology, Medical University of Graz, Austria. Retrospective, monocenter case-controlled study. Inclusion criteria for the study group and the control group were CME and no CME within 12 weeks following uneventful phacoemulsification in otherwise healthy eyes, respectively. VHDs (number and size) and the macular thickness were assessed with OCT. Furthermore, the number of peribulbar or intravitreal steroid injections was assessed. A total of 284 eyes from 267 patients were analyzed, among which 119 met the inclusion criteria for the study (n = 63) and the control group (n = 56). VHDs were observed in 54 (85.7%) study eyes and 21 (37.5%, p = 0.013) control eyes. The number of VHDs was 3.9±3.4 in the study group and 0.7±1 in the control group (p<0.001). The size of the VHDs was 33.5±9.1 μm and 36.6±17.9 μm in the study and control groups, respectively (p = 0.978). Overall, the number of VHDs correlated with central subfield thickness (r = 0.584, p<0.001), cube volume (r = 0.525, p<0.001), and postoperative best-corrected visual acuity (BCVA) (r = -0.563, p<0.001). The number of VHDs did not correlate with the frequency of peribulbar or intravitreal steroid injections. VHDs occurred more often in eyes with CME than in eyes without CME following cataract surgery. In addition, the number of VHDs had an impact on the extent of macular thickening and subsequently postoperative BCVA. No correlation was found between the number of VHDs and the frequency of required peribulbar or intravitreal steroid injections.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Aged, 80 and over -
Anti-Inflammatory Agents - therapeutic use
Case-Control Studies -
Cataract - diagnostic imaging
Cataract - physiopathology
Cortisone - therapeutic use
Female -
Humans -
Intravitreal Injections -
Macular Edema - diagnostic imaging
Macular Edema - drug therapy
Macular Edema - physiopathology
Macular Edema - surgery
Male -
Middle Aged -
Phacoemulsification -
Postoperative Period -
Pseudophakia - diagnostic imaging
Pseudophakia - drug therapy
Pseudophakia - physiopathology
Pseudophakia - surgery
Retrospective Studies -
Tomography, Optical Coherence -
Visual Acuity - physiology
Vitreous Body - diagnostic imaging
Vitreous Body - drug effects
Vitreous Body - surgery

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