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Rief, P; Raggam, RB; Hafner, F; Avian, A; Hackl, G; Cvirn, G; Brodmann, M; Gary, T.
Calculation of HAS-BLED Score Is Useful for Early Identification of Venous Thromboembolism Patients at High Risk for Major Bleeding Events: A Prospective Outpatients Cohort Study.
Semin Thromb Hemost. 2018; 44(4):348-352
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Autor/innen der Med Uni Graz:
Avian Alexander
Brodmann Marianne
Cvirn Gerhard
Gary Thomas
Hackl Gerald
Hafner Franz
Raggam Reinhard Bernd
Rief Peter
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Abstract:
The aim of this study was prospective evaluation of the performance of the HAS-BLED score in predicting major bleeding complications in a real-world outpatient cohort, during long-term anticoagulation for venous thromboembolism (VTE), treated with a broad spectrum of anticoagulants. We analyzed 111 outpatients objectively diagnosed with VTE and treated long-term with various anticoagulants. Patients were grouped in three cohorts based on the anticoagulant regimen. Calculation of the HAS-BLED score and documentation of bleeding events were performed every 6 months for 1 year. Patients with a HAS-BLED score ≥ 3 had an increased risk for major bleeding events (odds ratio [OR]: 13.05, 95% confidence interval [CI]: 0.96-692.58, p = 0.028) and a trend to higher risk for minor bleeding events as well (OR: 2.25, 95% CI: 0.87-5.85, p = 0.091) when compared with patients with a HAS-BLED score < 3.This indicates that a HAS-BLED score ≥ 3 allows for identification of patients with VTE on long-term anticoagulation at an increased risk for major bleeding events, irrespective of the anticoagulant agent used. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Aged -
Aged, 80 and over -
Anticoagulants - administration & dosage
Anticoagulants - adverse effects
Female -
Follow-Up Studies -
Hemorrhage - chemically induced
Hemorrhage - epidemiology
Humans -
Male -
Middle Aged -
Outpatients -
Prospective Studies -
Risk Factors -
Venous Thromboembolism - drug therapy
Venous Thromboembolism - epidemiology

Find related publications in this database (Keywords)
HAS-BLED score
venous thromboembolism
bleeding complications
anticoagulant treatment
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