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SHR Neuro Krebs Kardio Lipid

Azoulay, E; Pickkers, P; Soares, M; Perner, A; Rello, J; Bauer, PR; van de Louw, A; Hemelaar, P; Lemiale, V; Taccone, FS; Martin Loeches, I; Meyhoff, TS; Salluh, J; Schellongowski, P; Rusinova, K; Terzi, N; Mehta, S; Antonelli, M; Kouatchet, A; Barratt-Due, A; Valkonen, M; Landburg, PP; Bruneel, F; Bukan, RB; Pène, F; Metaxa, V; Moreau, AS; Souppart, V; Burghi, G; Girault, C; Silva, UVA; Montini, L; Barbier, F; Nielsen, LB; Gaborit, B; Mokart, D; Chevret, S; Efraim investigators and the Nine-I study group.
Acute hypoxemic respiratory failure in immunocompromised patients: the Efraim multinational prospective cohort study.
Intensive Care Med. 2017; 43(12):1808-1819
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Study Group Mitglieder der Med Uni Graz:
Amrein Karin

Dimensions Citations:

Plum Analytics:
In immunocompromised patients with acute hypoxemic respiratory failure (ARF), initial management aims primarily to avoid invasive mechanical ventilation (IMV). To assess the impact of initial management on IMV and mortality rates, we performed a multinational observational prospective cohort study in 16 countries (68 centers). A total of 1611 patients were enrolled (hematological malignancies 51.9%, solid tumors 35.2%, systemic diseases 17.3%, and solid organ transplantation 8.8%). The main ARF etiologies were bacterial (29.5%), viral (15.4%), and fungal infections (14.7%), or undetermined (13.2%). On admission, 915 (56.8%) patients were not intubated. They received standard oxygen (N = 496, 53.9%), high-flow oxygen (HFNC, N = 187, 20.3%), noninvasive ventilation (NIV, N = 153, 17.2%), and NIV + HFNC (N = 79, 8.6%). Factors associated with IMV included age (hazard ratio = 0.92/year, 95% CI 0.86-0.99), day-1 SOFA (1.09/point, 1.06-1.13), day-1 PaO2/FiO2 (1.47, 1.05-2.07), ARF etiology (Pneumocystis jirovecii pneumonia (2.11, 1.42-3.14), invasive pulmonary aspergillosis (1.85, 1.21-2.85), and undetermined cause (1.46, 1.09-1.98). After propensity score matching, HFNC, but not NIV, had an effect on IMV rate (HR = 0.77, 95% CI 0.59-1.00, p = 0.05). ICU, hospital, and day-90 mortality rates were 32.4, 44.1, and 56.4%, respectively. Factors independently associated with hospital mortality included age (odds ratio = 1.18/year, 1.09-1.27), direct admission to the ICU (0.69, 0.54-0.87), day-1 SOFA excluding respiratory score (1.12/point, 1.08-1.16), PaO2/FiO2 < 100 (1.60, 1.03-2.48), and undetermined ARF etiology (1.43, 1.04-1.97). Initial oxygenation strategy did not affect mortality; however, IMV was associated with mortality, the odds ratio depending on IMV conditions: NIV + HFNC failure (2.31, 1.09-4.91), first-line IMV (2.55, 1.94-3.29), NIV failure (3.65, 2.05-6.53), standard oxygen failure (4.16, 2.91-5.93), and HFNC failure (5.54, 3.27-9.38). HFNC has an effect on intubation but not on mortality rates. Failure to identify ARF etiology is associated with higher rates of both intubation and mortality. This suggests that in addition to selecting the appropriate oxygenation device, clinicians should strive to identify the etiology of ARF.
Find related publications in this database (using NLM MeSH Indexing)
Age Factors -
Aged -
Comorbidity -
Critical Illness -
Female -
Hospital Mortality -
Humans -
Hypoxia - mortality
Hypoxia - therapy
Immunocompromised Host -
Intubation, Intratracheal - adverse effects
Male -
Middle Aged -
Noninvasive Ventilation - methods
Organ Dysfunction Scores -
Oxygen Inhalation Therapy - methods
Prospective Studies -
Respiratory Insufficiency - etiology
Respiratory Insufficiency - mortality
Respiratory Insufficiency - therapy
Severity of Illness Index -

Find related publications in this database (Keywords)
Noninvasive ventilation
High flow oxygen
Hematological malignancies
Systemic diseases
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