Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Broadbent, J; Reichmuth, J; Trozic, I; Kneihsl, M; Rössler, A; Green, DA; Rodriguez, J; Hinghofer-Szalkay, H; Fazekas, F; Goswami, N.
Adrenomedullin and galanin responses to orthostasis in older persons.
Eur J Clin Invest. 2017; 47(11):812-818
Doi: 10.1111/eci.12803
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Goswami Nandu
- Co-Autor*innen der Med Uni Graz
- Fazekas Franz
- Hinghofer-Szalkay Helmut
- Kneihsl Markus
- Rössler Andreas
- Trozic Irhad
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Neuroendocrine responses to orthostasis may be critical in the maintenance of mean arterial pressure in healthy individuals. A greater reduction in orthostatic tolerance with age may relate to modulation of hormonal responses such as adrenomedullin and galanin. Thus, we investigated (i) whether adrenomedullin and galanin concentrations increase during orthostatic challenge in older subjects, (ii) whether adrenomedullin and galanin concentrations are higher in older females compared with older males when seated and during orthostatic challenge, and (iii) whether postural changes in plasma concentrations of galanin are correlated with levels of adrenomedullin in either older females or males. Subjects (n = 18; 12 ♀; 55-80 years old) performed a sit-to-stand test in a 25°C sensory-minimised environment, with blood samples collected after 4 min of being seated and then when standing. Plasma adrenomedullin and galanin concentrations were determined. Baseline plasma concentration of adrenomedullin (5·35 ± 0·74 (n = 12, females) vs. 7·40 ± 1·06 pg/mL (n = 5, males)) and galanin (64·07 ± 9·05 vs. 98·99 ± 16·90 pg/mL, respectively) did not significantly differ between genders. Furthermore, plasma adrenomedullin and galanin concentrations were not significantly affected by adoption of the upright posture in either gender and were not correlated in females or males. Adrenomedullin and galanin concentrations were similar between genders and did not change following adoption of the standing posture. To further clarify the roles, these hormones play in orthostatic intolerance, adrenomedullin and galanin concentrations should be assessed in participants who show presyncopal symptoms during an orthostatic challenge. © 2017 Stichting European Society for Clinical Investigation Journal Foundation.
- Find related publications in this database (using NLM MeSH Indexing)
- Adrenomedullin - metabolism
- Arterial Pressure - physiology
- Dizziness - blood
- Dizziness - etiology
- Female -
- Galanin - metabolism
- Humans -
- Male -
- Middle Aged -
- Posture -
- Prospective Studies -
- Find related publications in this database (Keywords)
- Adrenomedullin
- elderly
- galanin
- gender differences
- orthostatic challenge