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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Uphaus, T; Singer, OC; Berkefeld, J; Nolte, CH; Bohner, G; Niederkorn, K; Deutschmann, H; Haring, HP; Trenkler, J; Neumann-Haefelin, T; Hofmann, E; Stoll, A; Bormann, A; Bussmeyer, M; Mpotsaris, A; Reich, A; Wiesmann, M; Petzold, GC; Urbach, H; Jander, S; Turowski, B; Weimar, C; Schlamann, M; Liebeskind, DS; Gröschel, S; Boor, S; Gröschel, K.
Safety of endovascular treatment in acute stroke patients taking oral anticoagulants.
Int J Stroke. 2017; 12(4):412-415 Doi: 10.1177/1747493016677986 [OPEN ACCESS]
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Co-Autor*innen der Med Uni Graz
Deutschmann Hannes
Niederkorn Kurt

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Background The endovascular treatment of acute cerebral ischemia has been proven beneficial without major safety concerns. To date, the role of endovascular treatment in patients treated with oral anticoagulants, which may be associated with periprocedural intracranial bleeding, remains uncertain. Aims The objective of the current analysis is to evaluate the safety of endovascular treatment in patients treated with oral anticoagulants. Methods The ENDOSTROKE-Registry is a commercially independent, prospective observational study in 12 stroke centers in Germany and Austria collecting pre-specified variables about endovascular stroke therapy. Results Data from 815 patients (median age 70 (interquartile range (IQR) 20), 57% male) undergoing endovascular treatment with known anticoagulation status were analyzed. A total of 85 (median age 76 (IQR 8), 52% male) patients (10.4%) took vitamin-K-antagonists prior to endovascular treatment. Anticoagulation status as measured with international normalized ratio was above 2.0 in 31 patients. Intracranial hemorrhage occurred in 11.8% of patients taking vitamin-K-antagonists compared to no-vitamin-K-antagonists (12.2%, p = 0.909). After adjustment for confounding factors which were unbalanced at univariate level such as NIHSS and age, anticoagulation status was not found to significantly influence clinical outcome (modified Rankin Scale 3-6) and occurrence of intracranial hemorrhage in a multivariate logistic regression analysis. Conclusion Prior use of vitamin-K-antagonists was not associated with a higher rate of periprocedural intracranial hemorrhage after endovascular treatment or worse outcome. Endovascular treatment should be considered as an important treatment option in patients taking vitamin-K-antagonists.
Find related publications in this database (using NLM MeSH Indexing)
Administration, Oral -
Aged -
Aged, 80 and over -
Anticoagulants - administration & dosage
Anticoagulants - adverse effects
Anticoagulants - therapeutic use
Brain Ischemia - complications
Brain Ischemia - drug therapy
Female -
Humans -
Intracranial Hemorrhages - drug therapy
Intracranial Hemorrhages - etiology
Male -
Middle Aged -
Prospective Studies -
Registries -
Stroke - drug therapy
Stroke - surgery
Thrombolytic Therapy - methods
Treatment Outcome -

Find related publications in this database (Keywords)
Ischaemic stroke
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