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SHR Neuro Krebs Kardio Lipid

Wurzer, P; Cole, MR; Clayton, RP; Hundeshagen, G; Nunez Lopez, O; Cambiaso-Daniel, J; Winter, R; Branski, LK; Hawkins, HK; Finnerty, CC; Herndon, DN; Lee, JO.
Herpesviradae infections in severely burned children.
Burns. 2017; 43(5):987-992 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Branski Ludwik
Cambiaso-Daniel Janos
Winter Raimund
Wurzer Paul
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Number of Figures: 3
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Abstract:
Burn-related immunosuppression can promote human herpesviridae infections. However, the effect of these infections on morbidity and mortality after pediatric burn injuries is unclear. We retrospectively analyzed pediatric patients with burns ≥10% of the total body surface area (TBSA) who were admitted between 2010 and 2015. On clinical suspicion of a viral infection, antiviral therapy was initiated. Viral infection was confirmed via Tzanck smear, viral culture, and/or PCR. Study endpoints were mortality, days of antiviral agent administration, type of viral test used, type of viral infection, and length of hospitalization. Of the 613 patients were analyzed, 28 presented with clinically diagnosed viral infections. The use of Tzanck smears decreased over the past 5 years, whereas PCR and viral cultures have become standard. Patients with viral infections had significantly larger burns (53±15% vs. 38±18%, p<0.001); however, length of stay per TBSA burn was comparable (0.5±0.4 vs. 0.6±0.2, p=0.211). The most commonly detected herpesviridae was herpes simplex virus 1. Two patients died due to sepsis, which was accompanied by HSV infection. The mortality rate among all patients (2.7%) was comparable to that in the infected group (7.1%, p=0.898). Acyclovir was given systemically for 9±8days (N=76) and/or topically for 9±9days for HSV (N=39, combination of both N=33). Ganciclovir was prescribed in three cases for CMV. Viral infections occur more commonly in patients suffering from larger burns, and HSV infections can contribute to mortality. Copyright © 2017 Elsevier Ltd and ISBI. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Antiviral Agents - therapeutic use
Burns - mortality
Burns - therapy
Burns - virology
Child -
Child, Preschool -
Female -
Herpesviridae - isolation & purification
Herpesviridae Infections - diagnosis
Herpesviridae Infections - drug therapy
Herpesviridae Infections - etiology
Humans -
Infant -
Male -
Polymerase Chain Reaction -
Retrospective Studies -
Risk Factors -
Sepsis - virology
Virology - methods
Wound Infection - diagnosis
Wound Infection - drug therapy
Wound Infection - virology

Find related publications in this database (Keywords)
Viral cultures
Cytomegalovirus
Tzanck smear
Polymerase chain reaction
Acyclovir
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