Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Enko, D; Mangge, H; Münch, A; Niedrist, T; Mahla, E; Metzler, H; Prüller, F.
Pneumatic tube system transport does not alter platelet function in optical and whole blood aggregometry, prothrombin time, activated partial thromboplastin time, platelet count and fibrinogen in patients on anti-platelet drug therapy.
Biochem Med (Zagreb). 2017; 27(1):217-224
Doi: 10.11613/BM.2017.023
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- Führende Autor*innen der Med Uni Graz
- Enko Dietmar
- Prüller Florian
- Co-Autor*innen der Med Uni Graz
- Mahla Elisabeth
- Mangge Harald
- Metzler Helfried
- Münch Andreas
- Niedrist Tobias
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- Abstract:
- The aim of this study was to assess pneumatic tube system (PTS) alteration on platelet function by the light transmission aggregometry (LTA) and whole blood aggregometry (WBA) method, and on the results of platelet count, prothrombin time (PT), activated partial thromboplastin time (APTT), and fibrinogen. Venous blood was collected into six 4.5 mL VACUETTE® 9NC coagulation sodium citrate 3.8% tubes (Greiner Bio-One International GmbH, Kremsmünster, Austria) from 49 intensive care unit (ICU) patients on dual anti-platelet therapy and immediately hand carried to the central laboratory. Blood samples were divided into 2 Groups: Group 1 samples (N = 49) underwent PTS (4 m/s) transport from the central laboratory to the distant laboratory and back to the central laboratory, whereas Group 2 samples (N = 49) were excluded from PTS forces. In both groups, LTA and WBA stimulated with collagen, adenosine-5'-diphosphate (ADP), arachidonic acid (AA) and thrombin-receptor-activated-peptide 6 (TRAP-6) as well as platelet count, PT, APTT, and fibrinogen were performed. No statistically significant differences were observed between blood samples with (Group 1) and without (Group 2) PTS transport (P values from 0.064 - 0.968). The AA-induced LTA (bias: 68.57%) exceeded the bias acceptance limit of ≤ 25%. Blood sample transportation with computer controlled PTS in our hospital had no statistically significant effects on platelet aggregation determined in patients with anti-platelet therapy. Although AA induced LTA showed a significant bias, the diagnostic accuracy was not influenced.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Blood Coagulation - drug effects
- Blood Platelets - drug effects
- Blood Specimen Collection - instrumentation
- Blood Specimen Collection - methods
- Female -
- Humans -
- Male -
- Middle Aged -
- Partial Thromboplastin Time -
- Platelet Activation - drug effects
- Platelet Aggregation - drug effects
- Platelet Aggregation Inhibitors - pharmacology
- Platelet Count -
- Platelet Function Tests - methods
- Prothrombin Time -
- Transportation - instrumentation
- Transportation - methods
- Find related publications in this database (Keywords)
- platelets
- platelet aggregation
- platelet function tests
- clinical laboratory services
- preanalytical phase