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Enko, D; Mangge, H; Münch, A; Niedrist, T; Mahla, E; Metzler, H; Prüller, F.
Pneumatic tube system transport does not alter platelet function in optical and whole blood aggregometry, prothrombin time, activated partial thromboplastin time, platelet count and fibrinogen in patients on anti-platelet drug therapy.
Biochem Med (Zagreb). 2017; 27(1):217-224 Doi: 10.11613/BM.2017.023 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Enko Dietmar
Prüller Florian
Co-Autor*innen der Med Uni Graz
Mahla Elisabeth
Mangge Harald
Metzler Helfried
Münch Andreas
Niedrist Tobias

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The aim of this study was to assess pneumatic tube system (PTS) alteration on platelet function by the light transmission aggregometry (LTA) and whole blood aggregometry (WBA) method, and on the results of platelet count, prothrombin time (PT), activated partial thromboplastin time (APTT), and fibrinogen. Venous blood was collected into six 4.5 mL VACUETTE® 9NC coagulation sodium citrate 3.8% tubes (Greiner Bio-One International GmbH, Kremsmünster, Austria) from 49 intensive care unit (ICU) patients on dual anti-platelet therapy and immediately hand carried to the central laboratory. Blood samples were divided into 2 Groups: Group 1 samples (N = 49) underwent PTS (4 m/s) transport from the central laboratory to the distant laboratory and back to the central laboratory, whereas Group 2 samples (N = 49) were excluded from PTS forces. In both groups, LTA and WBA stimulated with collagen, adenosine-5'-diphosphate (ADP), arachidonic acid (AA) and thrombin-receptor-activated-peptide 6 (TRAP-6) as well as platelet count, PT, APTT, and fibrinogen were performed. No statistically significant differences were observed between blood samples with (Group 1) and without (Group 2) PTS transport (P values from 0.064 - 0.968). The AA-induced LTA (bias: 68.57%) exceeded the bias acceptance limit of ≤ 25%. Blood sample transportation with computer controlled PTS in our hospital had no statistically significant effects on platelet aggregation determined in patients with anti-platelet therapy. Although AA induced LTA showed a significant bias, the diagnostic accuracy was not influenced.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Aged, 80 and over -
Blood Coagulation - drug effects
Blood Platelets - drug effects
Blood Specimen Collection - instrumentation
Blood Specimen Collection - methods
Female -
Humans -
Male -
Middle Aged -
Partial Thromboplastin Time -
Platelet Activation - drug effects
Platelet Aggregation - drug effects
Platelet Aggregation Inhibitors - pharmacology
Platelet Count -
Platelet Function Tests - methods
Prothrombin Time -
Transportation - instrumentation
Transportation - methods

Find related publications in this database (Keywords)
platelet aggregation
platelet function tests
clinical laboratory services
preanalytical phase
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