Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Haymerle, G; Kadletz, L; Wiebringhaus, R; Golabi, B; Mildner, M; Thurnher, D; Heiduschka, G.
ELMO3 predicts poor outcome in T1 laryngeal cancer.
Clin Otolaryngol. 2017; 42(6):1181-1186
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Thurnher Dietmar
Altmetrics:

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Abstract:
Despite the excellent overall survival of 92%-97% in early glottic cancer, recurrence rates of 13%-20% have not improved in the last decades. The engulfment and cell motility protein 3 (ELMO3) have been described as prognostic marker in patients with lung cancer. The aim of this study was to investigate the expression of ELMO3 in early laryngeal cancer patients treated with TLM and to evaluate its prognostic significance on clinical outcome. Forty-eight patients with glottic carcinoma (T1N0M0) that underwent primary treatment with TLM between 1994 and 2012 were analysed. ELMO3 expression of the tumour was assessed using immunohistochemistry and correlated with clinical data. Overall survival, disease-specific survival (DSS) and disease-free survival (DFS) rates RESULTS: Positive ELMO3 expression was found in 23% of the patients and was correlated with poor DSS and DFS (P<.05). This is the first study to show a prognostic effect of positive ELMO3 expression in early glottic carcinoma patients. © 2017 John Wiley & Sons Ltd.
Find related publications in this database (using NLM MeSH Indexing)
Adaptor Proteins, Signal Transducing - metabolism
Adult -
Aged -
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - surgery
Cytoskeletal Proteins - metabolism
Disease-Free Survival -
Female -
Glottis -
Humans -
Laryngeal Neoplasms - metabolism
Laryngeal Neoplasms - mortality
Laryngeal Neoplasms - surgery
Laser Therapy -
Male -
Microsurgery -
Middle Aged -
Neoplasm Staging -
Predictive Value of Tests -
Retrospective Studies -
Survival Rate -
Treatment Outcome -

Find related publications in this database (Keywords)
ELMO3
immunohistochemistry
laryngeal cancer
laryngeal squamous cell carcinoma
outcome
© Med Uni Graz Impressum