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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Paschalis, EP; Gamsjaeger, S; Hassler, N; Fahrleitner-Pammer, A; Dobnig, H; Stepan, JJ; Pavo, I; Eriksen, EF; Klaushofer, K.
Vitamin D and calcium supplementation for three years in postmenopausal osteoporosis significantly alters bone mineral and organic matrix quality.
Bone. 2017; 95(2):41-46 Doi: 10.1016/j.bone.2016.11.002
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Co-Autor*innen der Med Uni Graz
Dobnig Harald
Fahrleitner-Pammer Astrid

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Prospective, controlled clinical trials in postmenopausal osteoporosis typically compare effects of an active drug with placebo in addition to vitamin D and calcium supplementation in both treatment arms. While clinical benefits are documented, the effect of this supplementation in the placebo arm and in clinical practice on bone material composition properties is unknown. The purpose of the present study was to evaluate these bone quality indices (specifically mineral/matrix, nanoporosity, glycosaminoglycan content, mineral maturity/crystallinity, and pyridinoline content) in patients that either received long-term vitamin D (400-1200IU) and calcium (1.0-1.5g) supplementation, or did not. We have analyzed by Raman microspectroscopy the bone forming trabecular surfaces of iliac crest in pre-treatment samples of a teriparatide study and the endpoint biopsies of the control arm obtained from the HORIZON trial. In general, the mineral/matrix ratio and the glycosaminoglycan (GAG) content was higher while nanoporosity, (a surrogate for tissue water content), the mineral maturity/crystallinity (MMC) and the pyridinoline (Pyd) content was lower in patients without long-term supplementation. Moreover, all indices were significantly dependent on tissue age. In conclusion, vitamin D and calcium supplementation is associated with altered mineral and organic matrix properties. Copyright © 2016 Elsevier Inc. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Aged, 80 and over -
Amino Acids - metabolism
Analysis of Variance -
Bone Matrix - drug effects
Bone Matrix - metabolism
Calcification, Physiologic - drug effects
Calcium - pharmacology
Calcium - therapeutic use
Dietary Supplements -
Female -
Glycosaminoglycans - metabolism
Humans -
Nanoparticles - chemistry
Osteoporosis, Postmenopausal - drug therapy
Osteoporosis, Postmenopausal - physiopathology
Porosity -
Spectrum Analysis, Raman -
Vitamin D - pharmacology
Vitamin D - therapeutic use

Find related publications in this database (Keywords)
Bone quality
Vitamin D
Postmenopausal osteoporosis
Raman spectroscopy
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