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SHR Neuro Krebs Kardio Lipid

Grabner, GF; Zimmermann, R; Schicho, R; Taschler, U.
Monoglyceride lipase as a drug target: At the crossroads of arachidonic acid metabolism and endocannabinoid signaling.
Pharmacol Ther. 2017; 175:35-46 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Schicho Rudolf
Taschler Ulrike
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Number of Figures: 2
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Abstract:
Monoglyerides (MGs) are short-lived, intermediary lipids deriving from the degradation of phospho- and neutral lipids, and monoglyceride lipase (MGL), also designated as monoacylglycerol lipase (MAGL), is the major enzyme catalyzing the hydrolysis of MGs into glycerol and fatty acids. This distinct function enables MGL to regulate a number of physiological and pathophysiological processes since both MGs and fatty acids can act as signaling lipids or precursors thereof. The most prominent MG species acting as signaling lipid is 2-arachidonoyl glycerol (2-AG) which is the most abundant endogenous agonist of cannabinoid receptors in the body. Importantly, recent observations demonstrate that 2-AG represents a quantitatively important source for arachidonic acid, the precursor of prostaglandins and other inflammatory mediators. Accordingly, MGL-mediated 2-AG degradation affects lipid signaling by cannabinoid receptor-dependent and independent mechanisms. Recent genetic and pharmacological studies gave important insights into MGL's role in (patho-)physiological processes, and the enzyme is now considered as a promising drug target for a number of disorders including cancer, neurodegenerative and inflammatory diseases. This review summarizes the basics of MG (2-AG) metabolism and provides an overview on the therapeutic potential of MGL. Copyright © 2017 Elsevier Inc. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Arachidonic Acids - metabolism
Emotions -
Endocannabinoids - metabolism
Humans -
Inflammation - metabolism
Metabolic Diseases - metabolism
Monoacylglycerol Lipases - metabolism
Neoplasms - metabolism
Pain - metabolism
Signal Transduction -
Stress, Physiological -
Substance-Related Disorders - metabolism

Find related publications in this database (Keywords)
Monoglyceride lipase
MGL
MAGL
2-arachidonoyl glycerol
Arachidonic acid
Cannabinoid receptor
Eicosanoids
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