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Reich, O; Regauer, S.
Thin HSIL of the Cervix: Detecting a Variant of High-grade Squamous Intraepithelial Lesions With a p16INK4a Antibody.
Int J Gynecol Pathol. 2017; 36(1):71-75
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Autor/innen der Med Uni Graz:
Regauer Sigrid
Reich Olaf
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Abstract:
The WHO defines thin high-grade squamous intraepithelial lesions (HSIL) as a high-grade intraepithelial lesion of the cervix that is usually ≤9 cells thick. These lesions usually develop in early metaplastic squamous epithelium without anteceding low-grade squamous intraepithelial lesions (LSIL). The prevalence of thin HSIL is not well documented. We evaluated different characteristics of thin HSIL at time of treatment. We studied 25 formalin-fixed and paraffin-embedded conization specimens processed as step-serial sections. HSIL≤9 cells thick were classified as thin HSIL. HSIL≥10 cells thick were classified as classic HSIL. Immunohistochemical p16 staining was used to confirm lesions of thin HSIL. Overall, 19 (76%) specimens contained both thin HSIL and classic HSIL, 4 (16%) contained thin HSIL only, 1 (4%) contained classic-type HSIL only, and 1 (4%) contained thin HSIL and LSIL. Thin HSILs developed in both the columnar surface epithelium and deep cervical glandular epithelium. Most thin HSILs were 5 cells thick. All HSILs (thin and classic) were located inside the transformation zone and had a median horizontal extension of 8 mm (range, 0.3 to 21 mm). Our findings suggest that thin HSILs are frequent findings, that they coexist with classic HSIL, and preferably arise in the exposed parts of the transformation zone including the glandular crypts.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Antibodies -
Cervical Intraepithelial Neoplasia - diagnosis
Cervical Intraepithelial Neoplasia - metabolism
Cervical Intraepithelial Neoplasia - pathology
Cervix Uteri - metabolism
Cervix Uteri - pathology
Cyclin-Dependent Kinase Inhibitor p16 - metabolism
Female -
Humans -
Middle Aged -
Squamous Intraepithelial Lesions of the Cervix - diagnosis
Squamous Intraepithelial Lesions of the Cervix - metabolism
Squamous Intraepithelial Lesions of the Cervix - pathology
Uterine Cervical Neoplasms - diagnosis
Uterine Cervical Neoplasms - metabolism
Uterine Cervical Neoplasms - pathology
Young Adult -

Find related publications in this database (Keywords)
Cervix
Carcinogenesis
Thin High-grade squamous Intraepithelial Lesions
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