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Enko, D; Meinitzer, A; Mangge, H; Kriegshäuser, G; Halwachs-Baumann, G; Reininghaus, EZ; Bengesser, SA; Schnedl, WJ.
Concomitant Prevalence of Low Serum Diamine Oxidase Activity and Carbohydrate Malabsorption.
Can J Gastroenterol Hepatol. 2016; 2016(2):4893501-4893501 [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Bengesser Susanne
Enko Dietmar
Halwachs-Baumann Gabriele
Kriegshäuser Gernot
Mangge Harald
Meinitzer Andreas
Reininghaus Eva
Schnedl Wolfgang

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The aim of this retrospective study was to analyze the concomitant prevalence rates for lactose malabsorption (LM), fructose malabsorption (FM), and histamine intolerance (HI) in patients with so far unexplained gastrointestinal (GI) symptoms. A total of 439 outpatients, who presented unclear abdominal discomfort, underwent lactose (50 g) and fructose (25 g) hydrogen (H2) breath tests. Additionally, serum diamine oxidase (DAO) measurements were performed. Individuals with low serum DAO activity (<10 U/mL), GI symptoms, and response to histamine-free diet were diagnosed with HI. Of all 439 patients, 341 (77.7%) were found with 7 various GI conditions. In total, 94 (21.4%), 31 (7.1%), and 100 (22.8%) individuals presented LM, FM, or HI only, whereas 116 (26.4%) patients showed an overlap of GI entities investigated here. Interestingly, 89 out of 241 (36.9%) individuals with carbohydrate malabsorption were also diagnosed with HI (LM + HI: 52 [11.8%], FM + HI: 23 [5.2%], and LM + FM + HI 14 [3.2%] individuals). In conclusion different combinations of LM, FM, and HI are present in individuals with unclear abdominal discomfort/pain. In clinical practice we suggest testing for LM, FM, and additional HI in the diagnostic work-up of these patients. Depending on these various diagnoses possible, patients should get an individualized dietary advice.
Find related publications in this database (using NLM MeSH Indexing)
Abdominal Pain - blood
Abdominal Pain - diagnosis
Abdominal Pain - etiology
Adult -
Amine Oxidase (Copper-Containing) - blood
Breath Tests -
Carbohydrates - analysis
Diet -
Female -
Fructose - analysis
Gastrointestinal Diseases - blood
Gastrointestinal Diseases - complications
Gastrointestinal Diseases - epidemiology
Histamine - analysis
Humans -
Hydrogen - analysis
Lactose - analysis
Lactose Intolerance - complications
Lactose Intolerance - diagnosis
Malabsorption Syndromes - blood
Malabsorption Syndromes - complications
Male -
Middle Aged -
Prevalence -
Retrospective Studies -

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