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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Salnikov, AV; Kusumawidjaja, G; Rausch, V; Bruns, H; Gross, W; Khamidjanov, A; Ryschich, E; Gebhard, MM; Moldenhauer, G; Büchler, MW; Schemmer, P; Herr, I.
Cancer stem cell marker expression in hepatocellular carcinoma and liver metastases is not sufficient as single prognostic parameter.
Cancer Lett. 2009; 275(2):185-193
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Autor/innen der Med Uni Graz:
Schemmer Peter

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Recent findings suggest that the presence of cancer stem cells could be linked with patients' survival. We profiled suggested cancer stem cell markers in tissue specimens of hepatocellular carcinoma and colorectal carcinoma liver metastases. About 1% of cells co-expressed cancer stem cell antigens, but there was no correlation between the amount of CD133(+), CD133(+)/CD44(+) or CD133(+)/CD24(-) cells and the patients' clinical-pathological status or with the cancer stem cell marker-positive cells localization. CD133(+) and CD133(-) fractions of Huh7 cells did not differ in migratory properties. Therefore, presence of markers alone should be taken with caution as single prognostic parameters.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Antigens, CD - metabolism
Biomarkers, Tumor - metabolism
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - secondary
Colorectal Neoplasms - pathology
Female -
Fluorescent Antibody Technique -
Humans -
Immunophenotyping -
Liver Neoplasms - metabolism
Liver Neoplasms - pathology
Liver Neoplasms - secondary
Male -
Middle Aged -
Neoplastic Stem Cells - immunology
Neoplastic Stem Cells - metabolism
Prognosis -

Find related publications in this database (Keywords)
Cancer stem cells
Tumour-initiating cells
Hepatocellular carcinoma
Colorectal carcinoma
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