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Sadovnick, AD; Traboulsee, AL; Bernales, CQ; Ross, JP; Forwell, AL; Yee, IM; Guillot-Noel, L; Fontaine, B; Cournu-Rebeix, I; Alcina, A; Fedetz, M; Izquierdo, G; Matesanz, F; Hilven, K; Dubois, B; Goris, A; Astobiza, I; Alloza, I; Antigüedad, A; Vandenbroeck, K; Akkad, DA; Aktas, O; Blaschke, P; Buttmann, M; Chan, A; Epplen, JT; Gerdes, LA; Kroner, A; Kubisch, C; Kümpfel, T; Lohse, P; Rieckmann, P; Zettl, UK; Zipp, F; Bertram, L; Lill, CM; Fernandez, O; Urbaneja, P; Leyva, L; Alvarez-Cermeño, JC; Arroyo, R; Garagorri, AM; García-Martínez, A; Villar, LM; Urcelay, E; Malhotra, S; Montalban, X; Comabella, M; Berger, T; Fazekas, F; Reindl, M; Schmied, MC; Zimprich, A; Vilariño-Güell, C.
Analysis of Plasminogen Genetic Variants in Multiple Sclerosis Patients.
G3 (Bethesda). 2016; 6(7):2073-2079 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Fazekas Franz
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Abstract:
Multiple sclerosis (MS) is a prevalent neurological disease of complex etiology. Here, we describe the characterization of a multi-incident MS family that nominated a rare missense variant (p.G420D) in plasminogen (PLG) as a putative genetic risk factor for MS. Genotyping of PLG p.G420D (rs139071351) in 2160 MS patients, and 886 controls from Canada, identified 10 additional probands, two sporadic patients and one control with the variant. Segregation in families harboring the rs139071351 variant, identified p.G420D in 26 out of 30 family members diagnosed with MS, 14 unaffected parents, and 12 out of 30 family members not diagnosed with disease. Despite considerably reduced penetrance, linkage analysis supports cosegregation of PLG p.G420D and disease. Genotyping of PLG p.G420D in 14446 patients, and 8797 controls from Canada, France, Spain, Germany, Belgium, and Austria failed to identify significant association with disease (P = 0.117), despite an overall higher prevalence in patients (OR = 1.32; 95% CI = 0.93-1.87). To assess whether additional rare variants have an effect on MS risk, we sequenced PLG in 293 probands, and genotyped all rare variants in cases and controls. This analysis identified nine rare missense variants, and although three of them were exclusively observed in MS patients, segregation does not support pathogenicity. PLG is a plausible biological candidate for MS owing to its involvement in immune system response, blood-brain barrier permeability, and myelin degradation. Moreover, components of its activation cascade have been shown to present increased activity or expression in MS patients compared to controls; further studies are needed to clarify whether PLG is involved in MS susceptibility. Copyright © 2016 Sadovnick et al.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Amino Acid Sequence -
Case-Control Studies -
Chromosomes, Human, Pair 6 - chemistry
Chromosomes, Human, Pair 6 - metabolism
Exome -
Female -
Gene Expression -
Genotype -
Humans -
Male -
Middle Aged -
Multiple Sclerosis - genetics
Multiple Sclerosis - pathology
Pedigree -
Plasminogen - genetics
Polymorphism, Single Nucleotide -
Risk Factors -
Sequence Alignment -
Sequence Homology, Amino Acid -

Find related publications in this database (Keywords)
multiple sclerosis
genetics
linkage
association
plasminogen
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