Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gattringer, T; Khalil, M; Langkammer, C; Jehna, M; Pichler, A; Pinter, D; Kneihsl, M; Petrovic, K; Ropele, S; Fazekas, F; Enzinger, C.
No evidence for increased brain iron deposition in patients with ischemic white matter disease.
Neurobiol Aging. 2016; 45(7):61-63
Doi: 10.1016/j.neurobiolaging.2016.05.008
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Gattringer Thomas
- Khalil Michael
- Co-Autor*innen der Med Uni Graz
- Enzinger Christian
- Fazekas Franz
- Jehna Margit
- Kneihsl Markus
- Langkammer Christian
- Petrovic Katja-Elisabeth
- Pichler Alexander
- Pinter Daniela Theresia
- Ropele Stefan
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- Abstract:
- Besides specific iron accumulation in some neurodegenerative disorders, increased iron deposition in cerebral deep gray matter (DGM) is found in multiple sclerosis. As this is considered largely a white matter (WM) disease, we speculated that patients with more severe ischemic WM hyperintensities (WMH) might also have an increased iron concentration in DGM structures and tested this assumption by using magnetic resonance imaging-based quantitative R2* relaxometry. WMH severity was measured in 61 patients with acute transient neurological symptoms (mean age: 71.5 ± 8.3 years) undergoing 3-Tesla magnetic resonance imaging. Despite a 6-year higher age of patients with more severe (i.e., early confluent or confluent) WMH, their DGM R2* rates did not differ from patients with punctate or no WMH. In the globus pallidum, R2* rates were even lower in patients with severe WMH. WMH volume was not correlated with R2* levels in any of the analyzed DGM structures. These findings argue against WM damage per se causing increased DGM iron deposition in multiple sclerosis and suggest no role of iron accumulation in ischemic small vessel disease. Copyright © 2016 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Brain Ischemia - metabolism
- Diffusion Magnetic Resonance Imaging -
- Female -
- Gray Matter - diagnostic imaging
- Gray Matter - metabolism
- Humans -
- Male -
- Middle Aged -
- Severity of Illness Index -
- White Matter - blood supply
- White Matter - diagnostic imaging
- Find related publications in this database (Keywords)
- Brain iron
- White matter hyperintensities
- Cerebral small vessel disease
- MRI
- R2*relaxation rate mapping