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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Gattringer, T; Khalil, M; Langkammer, C; Jehna, M; Pichler, A; Pinter, D; Kneihsl, M; Petrovic, K; Ropele, S; Fazekas, F; Enzinger, C.
No evidence for increased brain iron deposition in patients with ischemic white matter disease.
Neurobiol Aging. 2016; 45(7):61-63 Doi: 10.1016/j.neurobiolaging.2016.05.008
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Führende Autor*innen der Med Uni Graz
Gattringer Thomas
Khalil Michael
Co-Autor*innen der Med Uni Graz
Enzinger Christian
Fazekas Franz
Jehna Margit
Kneihsl Markus
Langkammer Christian
Petrovic Katja-Elisabeth
Pichler Alexander
Pinter Daniela Theresia
Ropele Stefan

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Besides specific iron accumulation in some neurodegenerative disorders, increased iron deposition in cerebral deep gray matter (DGM) is found in multiple sclerosis. As this is considered largely a white matter (WM) disease, we speculated that patients with more severe ischemic WM hyperintensities (WMH) might also have an increased iron concentration in DGM structures and tested this assumption by using magnetic resonance imaging-based quantitative R2* relaxometry. WMH severity was measured in 61 patients with acute transient neurological symptoms (mean age: 71.5 ± 8.3 years) undergoing 3-Tesla magnetic resonance imaging. Despite a 6-year higher age of patients with more severe (i.e., early confluent or confluent) WMH, their DGM R2* rates did not differ from patients with punctate or no WMH. In the globus pallidum, R2* rates were even lower in patients with severe WMH. WMH volume was not correlated with R2* levels in any of the analyzed DGM structures. These findings argue against WM damage per se causing increased DGM iron deposition in multiple sclerosis and suggest no role of iron accumulation in ischemic small vessel disease. Copyright © 2016 Elsevier Inc. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Aged, 80 and over -
Brain Ischemia - metabolism
Diffusion Magnetic Resonance Imaging -
Female -
Gray Matter - diagnostic imaging
Gray Matter - metabolism
Humans -
Male -
Middle Aged -
Severity of Illness Index -
White Matter - blood supply
White Matter - diagnostic imaging

Find related publications in this database (Keywords)
Brain iron
White matter hyperintensities
Cerebral small vessel disease
R2*relaxation rate mapping
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