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Mörkl, S; Müller, NJ; Blesl, C; Wilkinson, L; Tmava, A; Wurm, W; Holl, AK; Painold, A.
Problem solving, impulse control and planning in patients with early- and late-stage Huntington's disease.
Eur Arch Psychiatry Clin Neurosci. 2016; 266(7):663-671 Doi: 10.1007/s00406-016-0707-4 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Mittmannsgruber Claudia
Mörkl Sabrina
Co-Autor*innen der Med Uni Graz
Holl Anna
Painold Annamaria
Tmava-Berisha Adelina
Wurm Walter Ernst

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Sub-domains of executive functions, including problems with planning, accuracy, impulsivity, and inhibition, are core features of Huntington's disease. It is known that the decline of cognitive function in Huntington's disease is related to the anatomical progression of pathology in the basal ganglia. However, it remains to be determined whether the severity of executive dysfunction depends on the stage of the disease. To examine the severity of sub-domains of executive dysfunction in early- and late-stage Huntington's disease, we studied performance in the Tower of London task of two groups of Huntington's disease patients (Group 1: early, n = 23, and Group 2: late stage, n = 29), as well as a third group of age, education, and IQ matched healthy controls (n = 34). During the task, we measured the total number of problems solved, total planning time, and total number of breaks taken. One aspect of executive function indexed by the number of solved problems seems to progress in the course of the disease. Late-stage Huntington's disease patients scored significantly worse than early-stage patients and controls, and early-stage patients scored significantly worse than controls on this measure of accuracy. In contrast, late- and early-stage HD patients did not differ in terms of planning time and number of breaks. Early- and late-stage HD pathology has a different impact on executive sub-domains. While accuracy differs between early- and late-stage HD patients, other domains like planning time and number of breaks do not. Striatal degeneration, which is a characteristic feature of the disease, might not affect all aspects of executive function in HD.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Cognitive Dysfunction - etiology
Cognitive Dysfunction - physiopathology
Executive Function - physiology
Female -
Humans -
Huntington Disease - complications
Huntington Disease - physiopathology
Impulsive Behavior - physiology
Inhibition, Psychological -
Male -
Middle Aged -
Problem Solving - physiology
Severity of Illness Index -

Find related publications in this database (Keywords)
Huntington's disease
Executive function
Tower of London
Disease severity
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