Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Dehghan Esmatabadi, MJ; Farhangi, B; Safari, Z; Kazerooni, H; Shirzad, H; Zolghadr, F; Sadeghizadeh, M.
Dendrosomal curcumin inhibits metastatic potential of human SW480 colon cancer cells through Down-regulation of Claudin1, Zeb1 and Hef1-1 gene expression.
Asian Pac J Cancer Prev. 2015; 16(6):2473-2481 [OPEN ACCESS]


Autor/innen der Med Uni Graz:
Safari Zahra

Dimensions Citations:

Plum Analytics:
Colon cancer is one of the leading causes of cancer-associated death worldwide. The prognosis for advanced colorectal cancers remains dismal, mainly due to the propensity for metastatic progression. Accordingly, there is a need for effective anti-metastasis therapeutic agents. Since a great body of research has indicated anticancer effects for curcumin, we investigated the effects of dendrosomal curcumin (DNC) on cellular migration and adhesion of human SW480 cells and possible molecular mechanisms involved. Different methods were applied in this study including MTT, Scratch and adhesion assays as well as real-time PCR and transwell chamber assays. Based on the results obtained, DNC inhibits metastasis by decreasing Hef 1, Zeb 1 and Claudin 1 mRNA levels and can reduce SW480 cell proliferation with IC50values of 15.9, 11.6 and 7.64 μM at 24, 48 and 72 h post-treatment. Thus it might be considered as a safe formulation for therapeutic purpose in colorectal cancer cases.
Find related publications in this database (using NLM MeSH Indexing)
Adaptor Proteins, Signal Transducing - antagonists & inhibitors
Adaptor Proteins, Signal Transducing - genetics
Adaptor Proteins, Signal Transducing - metabolism
Antineoplastic Agents - pharmacology
Apoptosis - drug effects
Blotting, Western -
Cell Adhesion - drug effects
Cell Movement - drug effects
Cell Proliferation - drug effects
Claudin-1 - antagonists & inhibitors
Claudin-1 - genetics
Claudin-1 - metabolism
Colonic Neoplasms - drug therapy
Colonic Neoplasms - metabolism
Colonic Neoplasms - secondary
Curcumin - chemistry
Curcumin - pharmacology
Drug Carriers -
Gene Expression Regulation, Neoplastic - drug effects
Homeodomain Proteins - antagonists & inhibitors
Homeodomain Proteins - genetics
Homeodomain Proteins - metabolism
Humans -
Immunoenzyme Techniques -
Nanocapsules - administration & dosage
Phosphoproteins - antagonists & inhibitors
Phosphoproteins - genetics
Phosphoproteins - metabolism
RNA, Messenger - genetics
Real-Time Polymerase Chain Reaction -
Reverse Transcriptase Polymerase Chain Reaction -
Transcription Factors - antagonists & inhibitors
Transcription Factors - genetics
Transcription Factors - metabolism
Tumor Cells, Cultured -
Zinc Finger E-box-Binding Homeobox 1 -

© Med Uni Graz Impressum