Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Brandenburg, VM; Kleber, ME; Vervloet, MG; Larsson, TE; Tomaschitz, A; Pilz, S; Stojakovic, T; Delgado, G; Grammer, TB; Marx, N; März, W; Scharnagl, H.
Soluble klotho and mortality: the Ludwigshafen Risk and Cardiovascular Health Study.
Atherosclerosis. 2015; 242(2):483-489
Doi: 10.1016/j.atherosclerosis.2015.08.017
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- März Winfried
- Pilz Stefan
- Scharnagl Hubert
- Stojakovic Tatjana
- Tomaschitz Andreas
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- Abstract:
- Experimental evidence suggests that soluble klotho (s-klotho), a co-receptor for fibroblast growth factor 23 (FGF23), may modulate cardiovascular risk through multiple mechanisms. However, the predictive value of s-klotho in patients remains unclear. Therefore, the present study examined in a large cohort of patients referred for coronary angiography whether s-klotho is associated with cardiovascular and total mortality. The longitudinal associations between baseline s-klotho and FGF23 concentrations and mortality were evaluated in 2948 participants of the Ludwigshafen Risk and Cardiovascular Health Study (LURIC), referred for coronary angiography. Mean age of participants was: 63 ± 10 years. Patients with diabetes mellitus (n = 1136) had elevated s-klotho: [440 (430-449) versus 414 (406-421) pg/mL, p < 0.001]. S-klotho decreased in parallel to glomerular filtration rate (GFR) and increased in parallel to FGF23. During a median follow-up of 9.9 years, 874 deaths (30%) occurred, 539 (18%) of which were cardiovascular. After adjustment for cardiovascular risk factors, the hazard ratios in the fourth quartile compared to the first quartile of s-klotho were 1.14 (95%CI, 0.94-1.38; p = 0.187) for all-cause mortality and 1.03 (95%CI, 0.80-1.31; p = 0.845) for cardiovascular mortality. Excess mortality prediction by high levels of baseline FGF23 was not modified by adjustment for baseline s-klotho levels. Klotho does not add predictive power to cardiovascular and mortality risk assessment in patients with normal renal function. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Biomarkers - metabolism
- Cardiovascular Diseases - blood
- Cardiovascular Diseases - mortality
- Coronary Angiography - methods
- Coronary Artery Disease - blood
- Female -
- Fibroblast Growth Factors - blood
- Follow-Up Studies -
- Germany -
- Glomerular Filtration Rate -
- Glucuronidase - blood
- Humans -
- Kidney - physiology
- Longitudinal Studies -
- Male -
- Middle Aged -
- Proportional Hazards Models -
- Prospective Studies -
- Risk Factors -
- Find related publications in this database (Keywords)
- Coronary artery disease
- Coronary angiography
- Fibroblast growth factor 23, FGF23
- Cardiovascular events
- Outcome