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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Brandenburg, VM; Kleber, ME; Vervloet, MG; Larsson, TE; Tomaschitz, A; Pilz, S; Stojakovic, T; Delgado, G; Grammer, TB; Marx, N; März, W; Scharnagl, H.
Soluble klotho and mortality: the Ludwigshafen Risk and Cardiovascular Health Study.
Atherosclerosis. 2015; 242(2):483-489 Doi: 10.1016/j.atherosclerosis.2015.08.017
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Co-Autor*innen der Med Uni Graz
März Winfried
Pilz Stefan
Scharnagl Hubert
Stojakovic Tatjana
Tomaschitz Andreas

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Experimental evidence suggests that soluble klotho (s-klotho), a co-receptor for fibroblast growth factor 23 (FGF23), may modulate cardiovascular risk through multiple mechanisms. However, the predictive value of s-klotho in patients remains unclear. Therefore, the present study examined in a large cohort of patients referred for coronary angiography whether s-klotho is associated with cardiovascular and total mortality. The longitudinal associations between baseline s-klotho and FGF23 concentrations and mortality were evaluated in 2948 participants of the Ludwigshafen Risk and Cardiovascular Health Study (LURIC), referred for coronary angiography. Mean age of participants was: 63 ± 10 years. Patients with diabetes mellitus (n = 1136) had elevated s-klotho: [440 (430-449) versus 414 (406-421) pg/mL, p < 0.001]. S-klotho decreased in parallel to glomerular filtration rate (GFR) and increased in parallel to FGF23. During a median follow-up of 9.9 years, 874 deaths (30%) occurred, 539 (18%) of which were cardiovascular. After adjustment for cardiovascular risk factors, the hazard ratios in the fourth quartile compared to the first quartile of s-klotho were 1.14 (95%CI, 0.94-1.38; p = 0.187) for all-cause mortality and 1.03 (95%CI, 0.80-1.31; p = 0.845) for cardiovascular mortality. Excess mortality prediction by high levels of baseline FGF23 was not modified by adjustment for baseline s-klotho levels. Klotho does not add predictive power to cardiovascular and mortality risk assessment in patients with normal renal function. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Biomarkers - metabolism
Cardiovascular Diseases - blood
Cardiovascular Diseases - mortality
Coronary Angiography - methods
Coronary Artery Disease - blood
Female -
Fibroblast Growth Factors - blood
Follow-Up Studies -
Germany -
Glomerular Filtration Rate -
Glucuronidase - blood
Humans -
Kidney - physiology
Longitudinal Studies -
Male -
Middle Aged -
Proportional Hazards Models -
Prospective Studies -
Risk Factors -

Find related publications in this database (Keywords)
Coronary artery disease
Coronary angiography
Fibroblast growth factor 23, FGF23
Cardiovascular events
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