Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Trummer, O; Langsenlehner, U; Krenn-Pilko, S; Pieber, TR; Obermayer-Pietsch, B; Gerger, A; Renner, W; Langsenlehner, T.
Vitamin D and prostate cancer prognosis: a Mendelian randomization study.
World J Urol. 2016; 34(4):607-611 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Gerger Armin
Krenn-Pilko Sabine
Langsenlehner Tanja
Langsenlehner Uwe
Obermayer-Pietsch Barbara
Pieber Thomas
Renner Wilfried
Trummer Olivia
Altmetrics:

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Abstract:
Decreased vitamin D levels have been associated with prostate cancer, but it is unclear whether this association is causal. A functional single-nucleotide polymorphism (SNP) in the group-specific component (GC) gene (T > G, rs2282679) has been associated with 25-hydroxy (25-OH) vitamin D and 1.25 dihydroxy (1.25-OH2) vitamin D levels. To examine the hypothesized inverse relationship between vitamin D status and prostate cancer, we studied the association between this SNP and prostate cancer outcome in the prospective PROCAGENE study comprising 702 prostate cancer patients with a median follow-up of 82 months. GC rs2282679 genotypes were not associated with biochemical recurrence [hazard ratios (HR) 0.91, 95 % confidence interval (CI) 0.73-1.12; p = 0.36], development of metastases (HR 1.20, 95 % CI 0.88-1.63; p = 0.25) or overall survival (HR 1.10; 95 % CI 0.84-1.43; p = 0.50). A causal role of vitamin D status, as reflected by GC rs2282679 genotype, in disease progression and mortality in prostate cancer patients is unlikely.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Austria - epidemiology
Biomarkers, Tumor - blood
Biomarkers, Tumor - genetics
DNA, Neoplasm - genetics
Disease Progression -
Genotype -
Humans -
Male -
Mendelian Randomization Analysis - methods
Polymorphism, Single Nucleotide -
Prognosis -
Prospective Studies -
Prostatic Neoplasms - blood
Prostatic Neoplasms - genetics
Prostatic Neoplasms - mortality
Risk Factors -
Survival Rate - trends
Vitamin D-Binding Protein - blood
Vitamin D-Binding Protein - genetics

Find related publications in this database (Keywords)
Vitamin D
Prostate cancer
Genetics
© Med Uni Graz Impressum