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Lerchbaum, E; Schwetz, V; Nauck, M; Völzke, H; Wallaschofski, H; Hannemann, A.
Lower bone turnover markers in metabolic syndrome and diabetes: the population-based Study of Health in Pomerania.
Nutr Metab Cardiovasc Dis. 2015; 25(5):458-463 Doi: 10.1016/j.numecd.2015.02.002
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Führende Autor*innen der Med Uni Graz
Lerchbaum Elisabeth
Co-Autor*innen der Med Uni Graz
Theiler-Schwetz Verena

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Accumulating evidence demonstrates an important interaction between bone and energy metabolism. We aimed to study the associations of three bone turnover markers (BTM: osteocalcin, beta-crosslaps, procollagen type 1 N-terminal propeptide) as well as of 25-hydroxyvitamin D and parathyroid hormone with metabolic syndrome (MetS) or type 2 diabetes mellitus (T2DM) in a large population-based cohort. This cross-sectional study comprised 2671 adult men and women participating in the first follow-up of the population-based Study of Health in Pomerania (SHIP-1). Multivariable logistic regression analyses were performed to assess sex-specific associations between the BTMs, 25-hydroxyvitamin D or parathyroid hormone and metabolic disease. All models were adjusted for age, body mass index, smoking status, physical activity, estimated glomerular filtration rate and month of blood sampling. The models for women were further adjusted for menopausal status. Higher BTM or 25-hydroxyvitamin D concentrations were associated with significantly lower odds for metabolic disease, while there was no association between parathyroid hormone and MetS or T2DM. Our results contribute to the accumulating evidence of a cross-sectional association between high BTM or 25-hydroxyvitamin D concentrations and a lower prevalence of MetS or T2DM. Further research is necessary to evaluate the mechanisms underlying these results. Copyright © 2015 Elsevier B.V. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Biomarkers - blood
Bone Remodeling -
Cohort Studies -
Collagen - blood
Cross-Sectional Studies -
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - metabolism
Down-Regulation -
Female -
Follow-Up Studies -
Germany - epidemiology
Humans -
Male -
Metabolic Syndrome - blood
Metabolic Syndrome - epidemiology
Metabolic Syndrome - metabolism
Middle Aged -
Osteocalcin - blood
Parathyroid Hormone - blood
Peptide Fragments - blood
Prevalence -
Procollagen - blood
Vitamin D - analogs & derivatives
Vitamin D - blood
Young Adult -

Find related publications in this database (Keywords)
Procollagen type 1 N-terminal propeptide
25-hydroxyvitamin D
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