Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lerchbaum, E; Schwetz, V; Nauck, M; Völzke, H; Wallaschofski, H; Hannemann, A.
Lower bone turnover markers in metabolic syndrome and diabetes: the population-based Study of Health in Pomerania.
Nutr Metab Cardiovasc Dis. 2015; 25(5):458-463
Doi: 10.1016/j.numecd.2015.02.002
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Lerchbaum Elisabeth
- Co-Autor*innen der Med Uni Graz
- Theiler-Schwetz Verena
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- Abstract:
- Accumulating evidence demonstrates an important interaction between bone and energy metabolism. We aimed to study the associations of three bone turnover markers (BTM: osteocalcin, beta-crosslaps, procollagen type 1 N-terminal propeptide) as well as of 25-hydroxyvitamin D and parathyroid hormone with metabolic syndrome (MetS) or type 2 diabetes mellitus (T2DM) in a large population-based cohort. This cross-sectional study comprised 2671 adult men and women participating in the first follow-up of the population-based Study of Health in Pomerania (SHIP-1). Multivariable logistic regression analyses were performed to assess sex-specific associations between the BTMs, 25-hydroxyvitamin D or parathyroid hormone and metabolic disease. All models were adjusted for age, body mass index, smoking status, physical activity, estimated glomerular filtration rate and month of blood sampling. The models for women were further adjusted for menopausal status. Higher BTM or 25-hydroxyvitamin D concentrations were associated with significantly lower odds for metabolic disease, while there was no association between parathyroid hormone and MetS or T2DM. Our results contribute to the accumulating evidence of a cross-sectional association between high BTM or 25-hydroxyvitamin D concentrations and a lower prevalence of MetS or T2DM. Further research is necessary to evaluate the mechanisms underlying these results. Copyright © 2015 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Biomarkers - blood
- Bone Remodeling -
- Cohort Studies -
- Collagen - blood
- Cross-Sectional Studies -
- Diabetes Mellitus, Type 2 - blood
- Diabetes Mellitus, Type 2 - epidemiology
- Diabetes Mellitus, Type 2 - metabolism
- Down-Regulation -
- Female -
- Follow-Up Studies -
- Germany - epidemiology
- Humans -
- Male -
- Metabolic Syndrome - blood
- Metabolic Syndrome - epidemiology
- Metabolic Syndrome - metabolism
- Middle Aged -
- Osteocalcin - blood
- Parathyroid Hormone - blood
- Peptide Fragments - blood
- Prevalence -
- Procollagen - blood
- Vitamin D - analogs & derivatives
- Vitamin D - blood
- Young Adult -
- Find related publications in this database (Keywords)
- Osteocalcin
- Beta-crosslaps
- Procollagen type 1 N-terminal propeptide
- 25-hydroxyvitamin D