Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Thurnher, D; Kletzmayr, J; Formanek, M; Quint, C; Czerny, C; Burian, M; Kornek, G.
Chemotherapy-related hemolytic-uremic syndrome following treatment of a carcinoma of the nasopharynx.
Oncology. 2001; 61(2):143-146
Doi: 10.1159/000055365
(- Case Report)
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Thurnher Dietmar
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- Abstract:
- A cisplatin-containing regimen followed by radiation therapy is the recommended treatment for patients with advanced nasopharyngeal carcinoma. We report a case of a 58-year-old woman with hemolytic-uremic syndrome (HUS) who received induction chemotherapy for undifferentiated squamous cell carcinoma of the nasopharynx. During the 2nd course of chemotherapy (consisting of bleomycin, cisplatin and epirubicin), the patient developed hemolytic anemia, thrombocytopenia, and acute renal failure. After HUS had been diagnosed, the patient was transferred to the intensive care unit. Twice daily therapeutic plasma exchange (TPE) with fresh-frozen plasma, hemodialysis and high-dose cortisone was performed. Two weeks after the start of plasma exchange, thrombocytes and renal function began to normalize. Low-dose cortisone was continued until the patient recovered from hemolytic anemia. Six weeks after the administration of the second course of chemotherapy, the patient had fully recovered from HUS, and radiation therapy was carried out as planned. The patient responded well to treatment, but died 9 months after the diagnosis due to liver metastases. We demonstrated that early TPE with fresh-frozen plasma and high-dose cortisone is a potentially successful treatment modality for the usually fatal, fulminant form of chemotherapy-induced HUS. Copyright 2001 S. Karger AG, Basel
- Find related publications in this database (using NLM MeSH Indexing)
- Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use
- Bleomycin - administration & dosage
- Carcinoma, Squamous Cell - complications Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - radiotherapy
- Chemotherapy, Adjuvant - adverse effects
- Cisplatin - administration & dosage Cisplatin - adverse effects
- Combined Modality Therapy -
- Cortisone - therapeutic use
- Epirubicin - administration & dosage
- Fatal Outcome -
- Female -
- Hemolytic-Uremic Syndrome - chemically induced Hemolytic-Uremic Syndrome - drug therapy Hemolytic-Uremic Syndrome - therapy
- Humans -
- Middle Aged -
- Nasopharyngeal Neoplasms - complications Nasopharyngeal Neoplasms - drug therapy Nasopharyngeal Neoplasms - radiotherapy
- Plasma -
- Plasma Exchange -
- Renal Dialysis -
- Find related publications in this database (Keywords)
- nasopharyngeal carcinoma
- hemolytic uremic syndrome
- neoadjuvant chemotherapy
- radiation therapy