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Nardone, R; Höller, Y; Tezzon, F; Christova, M; Schwenker, K; Golaszewski, S; Trinka, E; Brigo, F.
Neurostimulation in Alzheimer's disease: from basic research to clinical applications.
Neurol Sci. 2015; 36(5):689-700 Doi: 10.1007/s10072-015-2120-6
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Co-Autor*innen der Med Uni Graz
Christova Monica

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The development of different methods of brain stimulation provides a promising therapeutic tool with potentially beneficial effects on subjects with impaired cognitive functions. We performed a systematic review of the studies published in the field of neurostimulation in Alzheimer's disease (AD), from basic research to clinical applications. The main methods of non-invasive brain stimulation are repetitive transcranial magnetic stimulation and transcranial direct current stimulation. Preliminary findings have suggested that both techniques can enhance performances on several cognitive functions impaired in AD. Another non-invasive emerging neuromodulatory approach, the transcranial electromagnetic treatment, was found to reverse cognitive impairment in AD transgenic mice and even improves cognitive performance in normal mice. Experimental studies suggest that high-frequency electromagnetic fields may be critically important in AD prevention and treatment through their action at mitochondrial level. Finally, the application of a widely known invasive technique, the deep brain stimulation (DBS), has increasingly been considered as a therapeutic option also for patients with AD; it has been demonstrated that DBS of fornix/hypothalamus and nucleus basalis of Meynert might improve or at least stabilize cognitive functioning in AD. Initial encouraging results provide support for continuing to investigate non-invasive and invasive brain stimulation approaches as an adjuvant treatment for AD patients.
Find related publications in this database (using NLM MeSH Indexing)
Alzheimer Disease - genetics
Alzheimer Disease - therapy
Animals -
Clinical Trials as Topic -
Electric Stimulation Therapy - methods
Humans -
Mice -
Mice, Transgenic -
Translational Medical Research -

Find related publications in this database (Keywords)
Alzheimer's disease
Repetitive transcranial magnetic stimulation
Transcranial direct current stimulation
Transcranial electromagnetic treatment
High-frequency electromagnetic field
Deep brain stimulation
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