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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Gori, M; Senni, M; Gupta, DK; Charytan, DM; Kraigher-Krainer, E; Pieske, B; Claggett, B; Shah, AM; Santos, AB; Zile, MR; Voors, AA; McMurray, JJ; Packer, M; Bransford, T; Lefkowitz, M; Solomon, SD; PARAMOUNT Investigators.
Association between renal function and cardiovascular structure and function in heart failure with preserved ejection fraction.
Eur Heart J. 2014; 35(48):3442-3451 Doi: 10.1093/eurheartj/ehu254 [OPEN ACCESS]
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Co-Autor*innen der Med Uni Graz
Kraigher-Krainer Elisabeth
Pieske Burkert Mathias

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Renal dysfunction is a common comorbidity in patients with heart failure and preserved ejection fraction (HFpEF). We sought to determine whether renal dysfunction was associated with measures of cardiovascular structure/function in patients with HFpEF. We studied 217 participants from the PARAMOUNT study with HFpEF who had echocardiography and measures of kidney function. We evaluated the relationships between renal dysfunction [estimated glomerular filtration rate (eGFR) >30 and <60 mL/min/1.73 m(2) and/or albuminuria] and cardiovascular structure/function. The mean age of the study population was 71 years, 55% were women, 94% hypertensive, and 40% diabetic. Impairment of at least one parameter of kidney function was present in 62% of patients (16% only albuminuria, 23% only low eGFR, 23% both). Renal dysfunction was associated with abnormal LV geometry (defined as concentric hypertrophy, or eccentric hypertrophy, or concentric remodelling) (adjusted P = 0.048), lower midwall fractional shortening (MWFS) (P = 0.009), and higher NT-proBNP (P = 0.006). Compared with patients without renal dysfunction, those with low eGFR and no albuminuria had a higher prevalence of abnormal LV geometry (P = 0.032) and lower MWFS (P < 0.01), as opposed to those with only albuminuria. Conversely, albuminuria alone was associated with greater LV dimensions (P < 0.05). Patients with combined renal impairment had mixed abnormalities (higher LV wall thicknesses, NT-proBNP; lower MWFS). Renal dysfunction, as determined by both eGFR and albuminuria, is highly prevalent in HFpEF, and associated with cardiac remodelling and subtle systolic dysfunction. The observed differences in cardiac structure/function between each type of renal damage suggest that both parameters of kidney function might play a distinct role in HFpEF. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email:
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Albuminuria - pathology
Albuminuria - physiopathology
Cardio-Renal Syndrome - pathology
Cardio-Renal Syndrome - physiopathology
Creatinine - urine
Echocardiography -
Female -
Glomerular Filtration Rate - physiology
Humans -
Hypertrophy, Left Ventricular - pathology
Hypertrophy, Left Ventricular - physiopathology
Male -
Prospective Studies -
Stroke Volume - physiology

Find related publications in this database (Keywords)
Heart failure with preserved ejection fraction
Chronic kidney disease
Glomerular filtration rate
Cardiovascular structure and function
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