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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Told, R; Schmidl, D; Palkovits, S; Boltz, A; Gouya, G; Wolzt, M; Witkowska, KJ; Popa-Cherecheanu, A; Werkmeister, RM; Garhöfer, G; Schmetterer, L.
Antioxidative capacity of a dietary supplement on retinal hemodynamic function in a human lipopolysaccharide (LPS) model.
Invest Ophthalmol Vis Sci. 2015; 56(1):403-411
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Palkovits Stefan
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Abstract:
Beneficial effects of dietary supplements in age-related macular degeneration (AMD) are related to antioxidative properties. In the Age-Related Eye Disease Study 1 (AREDS 1), a reduced progression to late stage AMD was found using vitamin C, E, zinc, and β-carotene. We showed previously that the AREDS 1 formulation restores the O2-induced retinal vasoconstrictor response of retinal vessels in a human endotoxin (lipopolysaccharide [LPS]) model. We hypothesized that the abnormal O2-induced retinal red blood cell (RBC) flow response can be modulated by a different formulation (vitamin C, E, and zinc, lutein/zeaxanthin, selenium, taurine, Aronia extract, and omega-3 free fatty acids). A total of 43 healthy subjects was included in this randomized, double masked, placebo-controlled parallel group study. The reactivity of retinal arterial and venous diameter, RBC velocity, and flow to 100% O2 breathing was investigated in the absence and presence of 2 ng/kg LPS. Between the two study days was a 14-day period of daily dietary supplement intake. The decrease in retinal arterial diameter, RBC velocity, and flow during 100% O2 breathing was diminished significantly after LPS infusion. Dietary supplement intake for 14 days almost restored the response of retinal hemodynamic parameters to 100% O2 after LPS administration. This effect was significant for retinal arterial diameter (P = 0.03 between groups), and RBC velocity and flow (each P < 0.01 between groups). The present data indicate restoring of the RBC flow response to 100% O2 after LPS administration. This is likely due to an amelioration of endothelial dysfunction resulting from oxidative stress, a factor involved in AMD pathophysiology. (ClinicalTrials.gov number, NCT00914576.). Copyright 2015 The Association for Research in Vision and Ophthalmology, Inc.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Antioxidants - administration & dosage
Dietary Supplements -
Double-Blind Method -
Female -
Follow-Up Studies -
Healthy Volunteers -
Hemodynamics - drug effects
Humans -
Laser-Doppler Flowmetry -
Lipopolysaccharides - adverse effects
Macular Degeneration - chemically induced
Male -
Regional Blood Flow -
Retina - drug effects
Retinal Vessels - drug effects
Treatment Outcome -
Young Adult -

Find related publications in this database (Keywords)
retinal hemodynamic function
retinal blood flow
dietary supplements
endotoxin model
young healthy subjects
red blood cell flow
white blood cell flow
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