Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Hofer, HP; Egger, G; Kukovetz, EM; Bratschitsch, G; Steindorfer, P; Schaur, RJ.
The influence of trauma on changes in neutrophil granulocyte function assessed by an analysis of granulocyte migration.
Langenbecks Arch Chir. 1996; 381(3):148-154
Doi: 10.1007/BF00187619
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Bratschitsch Gerhard
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- Abstract:
- We examined the effects of trauma on polymorphonuclear leucocyte (PMN) migratory parameters and PMN elastase release, with the aim of tracing an acute inflammatory reaction from its very beginning to the phase of recovery. Fifteen patients who underwent monotrauma surgery, followed by uneventful healing, served as inflammation model. PMN activation was studied by measuring their readiness to migrate (TMI) and their penetration potency (DC) in a whole blood membrane filter device, in which a chemoattractant depot (FMLP) was integrated. Control chambers lacking FMLP provided parameters of the spontaneous migration. In healthy controls (n = 64), the numbers of invading PMNs decreased continuously from the outermost layer towards the interior of the filter device. FMLP did not influence the mobilization rate of PMNs immigrant from the blood into the filter, but those cells that did migrate penetrated deeper (P < 0.05). After trauma, the spontaneous and FMLP-stimulated DC was increased (P < 0.05). Trauma also tended to inhibit PMN migratory activity episodically; depression of the unspecific immune function (low TMI values) was found on the 3rd (P < 0.0001) and 12th (P < 0.01) postsurgical days. There was no correlation between the migratory parameters and the inflammation parameter, PMN elastase release. Preliminary results indicate that analyses of PMN migratory parameters by a whole blood membrane filter assay could provide a valuable adjunct in monitoring trauma-associated immunologic changes.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute-Phase Reaction - immunology
- Adult -
- Aged -
- Aged, 80 and over -
- Cell Movement -
- Chemotaxis, Leukocyte - immunology
- Female -
- Fracture Fixation, Internal -
- Fractures, Bone - immunology Fractures, Bone - surgery
- Humans -
- Leukocyte Count -
- Leukocyte Elastase -
- Male -
- Middle Aged -
- Neutrophils - immunology
- Pancreatic Elastase - blood
- Postoperative Complications - immunology
- Reference Values -
- Wounds and Injuries - immunology Wounds and Injuries - surgery