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Seidel, G; Hausberger, S; Herzog, SA; Palkovits, S; Pöschl, EM; Wackernagel, W; Weger, M.
Circadian macular volume changes in the healthy human choroid.
Am J Ophthalmol. 2015; 159(2):365-371 Doi: 10.1016/j.ajo.2014.11.002
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Führende Autor*innen der Med Uni Graz
Seidel Gerald
Co-Autor*innen der Med Uni Graz
Herzog Sereina Annik
Malle Eva Maria Birgit
Palkovits Stefan
Pinter-Hausberger Silke
Wackernagel Werner
Weger Martin

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To investigate a potential circadian fluctuation of the choroidal volume in healthy adults by enhanced depth imaging (EDI) via spectral-domain optical coherence tomography (SD OCT). Prospective observational case series. Thirty healthy eyes of 15 healthy subjects with a median age of 26 years (range 22-55) underwent EDI SD OCT scans for macular choroidal volume measurement every 3 hours within a 24-hour period at a single tertiary center. The mean ocular perfusion pressure was calculated for each eye at each of the 8 time points as 2/3(mean arterial pressure-intraocular pressure [IOP]). The circadian fluctuation of the macular choroidal volume as well as the association with axial length, mean ocular perfusion pressure, or IOP was assessed using a linear mixed model. Macular choroidal volume showed a significant circadian fluctuation (P < .05) and was lowest at midday (mean ± SD, 10.14 ± 2.62 mm(3)) and highest at 3 AM (mean ± SD, 10.66 ± 2.70 mm(3)). Of all factors tested, only mean ocular perfusion pressure showed a significant association with macular choroidal volume fluctuation (P = .016). Macular choroidal volume shows a significant circadian pattern with higher values at night and lower values during the day in young adults. Besides time, mean ocular perfusion pressure is significantly associated with this fluctuation. Copyright © 2015 Elsevier Inc. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Arterial Pressure - physiology
Axial Length, Eye - anatomy & histology
Choroid - anatomy & histology
Circadian Rhythm - physiology
Female -
Healthy Volunteers -
Humans -
Intraocular Pressure - physiology
Male -
Middle Aged -
Prospective Studies -
Tomography, Optical Coherence -
Visual Acuity - physiology
Young Adult -

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