Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Seidel, G; Hausberger, S; Herzog, SA; Palkovits, S; Pöschl, EM; Wackernagel, W; Weger, M.
Circadian macular volume changes in the healthy human choroid.
Am J Ophthalmol. 2015; 159(2):365-371
Doi: 10.1016/j.ajo.2014.11.002
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Seidel Gerald
- Co-Autor*innen der Med Uni Graz
- Herzog Sereina Annik
- Malle Eva Maria Birgit
- Palkovits Stefan
- Pinter-Hausberger Silke
- Wackernagel Werner
- Weger Martin
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- Abstract:
- To investigate a potential circadian fluctuation of the choroidal volume in healthy adults by enhanced depth imaging (EDI) via spectral-domain optical coherence tomography (SD OCT). Prospective observational case series. Thirty healthy eyes of 15 healthy subjects with a median age of 26 years (range 22-55) underwent EDI SD OCT scans for macular choroidal volume measurement every 3 hours within a 24-hour period at a single tertiary center. The mean ocular perfusion pressure was calculated for each eye at each of the 8 time points as 2/3(mean arterial pressure-intraocular pressure [IOP]). The circadian fluctuation of the macular choroidal volume as well as the association with axial length, mean ocular perfusion pressure, or IOP was assessed using a linear mixed model. Macular choroidal volume showed a significant circadian fluctuation (P < .05) and was lowest at midday (mean ± SD, 10.14 ± 2.62 mm(3)) and highest at 3 AM (mean ± SD, 10.66 ± 2.70 mm(3)). Of all factors tested, only mean ocular perfusion pressure showed a significant association with macular choroidal volume fluctuation (P = .016). Macular choroidal volume shows a significant circadian pattern with higher values at night and lower values during the day in young adults. Besides time, mean ocular perfusion pressure is significantly associated with this fluctuation. Copyright © 2015 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Arterial Pressure - physiology
- Axial Length, Eye - anatomy & histology
- Choroid - anatomy & histology
- Circadian Rhythm - physiology
- Female -
- Healthy Volunteers -
- Humans -
- Intraocular Pressure - physiology
- Male -
- Middle Aged -
- Prospective Studies -
- Tomography, Optical Coherence -
- Visual Acuity - physiology
- Young Adult -