Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Herbert, MK; Holzer, P.
Interleukin-1 beta enhances capsaicin-induced neurogenic vasodilatation in the rat skin.
BRIT J PHARMACOL 1994 111: 681-686. [OPEN ACCESS]
Web of Science PubMed PUBMED Central Google Scholar

 

Autor/innen der Med Uni Graz:
Herbert Michael K.
Holzer Peter
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Abstract:
1. This study examined the effect of interleukin-1 beta (IL-1 beta) on the capsaicin-induced increase in cutaneous blood flow of anaesthetized rats as measured by laser Doppler flowmetry. 2. The substances were administered by intraplantar subcutaneous injection of 10 microliters-volumes, saline being injected into one hindpaw and IL-1 beta into the other. 3. IL-1 beta (0.5-500 pg) was without effect on blood flow on its own but dose-dependently enhanced the hyperaemic response to intraplantar capsaicin (0.3 microgram) up to 180% (P < 0.05) of the response seen in saline-treated paws. 4. Il-1 beta-(163-171), a fragment devoid of proinflammatory activity, failed to enhance capsaicin-induced hyperaemia when given at a dose of 50 pg. 5. Indomethacin (10 mg kg-1, i.p.) did not alter the capsaicin-induced vasodilatation but prevented IL-1 beta (50 pg) from augmenting the hyperaemic response to capsaicin. 6. The hyperaemia evoked by intraplantar calcitonin gene-related peptide (0.038-3.8 ng) was not altered by IL-1 beta (50 pg). 7. These data indicate that IL-1 beta enhances the cutaneous hyperaemic response to afferent nerve stimulation with capsaicin in a prostaglandin-dependent manner. This proinflammatory action of the cytokine appears to arise from sensitization of afferent nerve endings.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Blood Pressure - drug effects
Calcitonin Gene-Related Peptide - pharmacology
Capsaicin - pharmacology
Drug Synergism - pharmacology
Female - pharmacology
Hyperemia - chemically induced
Indomethacin - pharmacology
Interleukin-1 - pharmacology
Muscle, Smooth, Vascular - drug effects
Neurons, Afferent - drug effects
Rats - drug effects
Rats, Sprague-Dawley - drug effects
Research Support, Non-U.S. Gov't - drug effects
Skin - blood supply
Stimulation, Chemical - blood supply
Vasodilation - drug effects

Find related publications in this database (Keywords)
Interleukin-1-Beta
Capsaicin
Afferent Nerve Stimulation
Cutaneous Hyperemia
Neurogenic Inflammation
Sensitization of Afferent Nerve Endings
Proinflammatory Action
Prostaglandins
Calcitonin Gene-Related Peptide (CGRP)
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