Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wree, A; Schlattjan, M; Bechmann, LP; Claudel, T; Sowa, JP; Stojakovic, T; Scharnagl, H; Köfeler, H; Baba, HA; Gerken, G; Feldstein, AE; Trauner, M; Canbay, A.
Adipocyte cell size, free fatty acids and apolipoproteins are associated with non-alcoholic liver injury progression in severely obese patients.
Metabolism. 2014; 63(12):1542-1552
Doi: 10.1016/j.metabol.2014.09.001
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Trauner Michael
- Co-Autor*innen der Med Uni Graz
- Claudel Thierry
- Köfeler Harald
- Scharnagl Hubert
- Stojakovic Tatjana
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- Abstract:
- Obesity is a modern pandemic with continuous expansion and represents an independent risk factor for non-alcoholic fatty liver disease (NAFLD), the most common liver disease in westernized countries. The crosstalk between adipose tissue and the liver is key to the development of NAFLD. Therefore, in an observational study blood, visceral adipose tissue and liver tissue were obtained from 93 severely obese patients with a mean age of 43 years and mean BMI of 52 kg/m2 at the time of weight loss surgery. In a subset of patients a follow-up blood sample was obtained 6 weeks after surgery to assess acute effects of weight loss. In addition to routine parameters of liver injury, serum samples were analyzed for leptin, adiponectin, free fatty acids (FFAs), and several apolipoproteins. The diameter of visceral adipocytes correlated to liver injury, serum markers of inflammation and serum adipokine levels. Liver injury assessed by serology (ALT, AST) and histology (NAFLD activity score, NAS) was independent of the BMI. However, serum levels of triglycerides and Apolipoprotein CIII (ApoCIII) were associated with NAS. Serum levels and composition of FFAs, especially long chain FFAs, also correlated with NAS. Analysis of serum samples six weeks after surgery revealed beneficial changes in serum triglycerides, levels of ApoCIII and several FFAs. In severely obese patients beneficial effects on liver injury can been observed as early as six weeks after bariatric surgery. These effects may be explained by the observed changes in adipose tissue and lipid metabolism. Collectively, these findings underline the importance of the link between adipose tissue and the liver. Copyright © 2014 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adipocytes - physiology
- Adiponectin - metabolism
- Adult -
- Apolipoproteins - blood
- Bariatric Surgery -
- C-Reactive Protein - metabolism
- Cell Size -
- Cohort Studies -
- Disease Progression -
- Fatty Acids, Nonesterified - blood
- Female -
- Humans -
- Leptin - metabolism
- Male -
- Middle Aged -
- Non-alcoholic Fatty Liver Disease - enzymology Non-alcoholic Fatty Liver Disease - pathology
- Obesity - metabolism Obesity - pathology Obesity - surgery
- Severity of Illness Index -
- Find related publications in this database (Keywords)
- Obesity
- Hepatology
- Bariatric surgery
- Non-alcoholic fatty liver disease
- Adipose tissue