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Esmaeelpour, M; Ansari-Shahrezaei, S; Glittenberg, C; Nemetz, S; Kraus, MF; Hornegger, J; Fujimoto, JG; Drexler, W; Binder, S.
Choroid, Haller's, and Sattler's layer thickness in intermediate age-related macular degeneration with and without fellow neovascular eyes.
Invest Ophthalmol Vis Sci. 2014; 55(8):5074-5080 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Autor/innen der Med Uni Graz:
Ansari Shahrezaei Siamak

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Number of Figures: 2
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To analyze choroidal, Sattler's, and Haller's layer thickness maps in age-related macular degeneration (AMD) patients having eyes with bilateral large drusen and pigment changes (intermediate AMD), in patients having intermediate AMD eyes with neovascular fellow eyes (nAMD), and in healthy subjects using three-dimensional (3D) 1060-nm optical coherence tomography (OCT). Automatically generated choroidal thickness (ChT), retinal thickness, and Sattler's and Haller's layer thickness maps were statistically analyzed in 67 subjects consisting of intermediate AMD (n = 21), intermediate AMD (n = 22) with fellow nAMD eyes (n = 22), and healthy eyes (n = 24) with no age and axial eye length difference between groups of eyes (P > 0.05, ANOVA). Eyes were imaged by a prototype high-speed (60,000 A-scans/s) spectral-domain 3D 1060-nm OCT over a 36° × 36° field of view. The mean ± SD (μm) subfoveal ChT for healthy subjects and for bilateral intermediate AMD, unilateral intermediate AMD, and their nAMD fellow eyes was 259 ± 95 and 222 ± 98, 149 ± 60, and 171 ± 78, respectively. Choroidal thickness maps demonstrated significant submacular thinning in unilateral intermediate AMD in comparison to healthy and bilateral intermediate AMD eyes (P < 0.001, ANOVA, post hoc P < 0.001 and P < 0.05, respectively). Sattler's and Haller's layers were thinnest in intermediate AMDs that presented with nAMD fellow eyes (Kruskal-Wallis test P < 0.01). For the choroid and its sublayers, there was no difference between the intermediate AMD eyes and their fellow nAMD eyes (paired testing, P < 0.05). The 3D 1060-nm OCT choroidal imaging visualized significant changes in choroidal, Sattler's, and Haller's layer thickness in relation to the progression of AMD. This may be important for understanding the choroidopathy in the pathophysiology of AMD. Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Aged, 80 and over -
Choroid - pathology
Choroidal Neovascularization - complications
Choroidal Neovascularization - pathology
Disease Progression -
Female -
Follow-Up Studies -
Humans -
Imaging, Three-Dimensional -
Macular Degeneration - complications
Macular Degeneration - pathology
Male -
Middle Aged -
Prospective Studies -
Retina - pathology
Retinal Neovascularization - complications
Retinal Neovascularization - pathology
Tomography, Optical Coherence - methods

Find related publications in this database (Keywords)
age-related macular degeneration
optical coherence tomography
choroidal thickness maps
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