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SHR Neuro Krebs Kardio Lipid

Tilki, D; Hu, B; Nguyen, HG; Dall'Era, MA; Bertini, R; Carballido, JA; Chandrasekar, T; Chromecki, T; Ciancio, G; Daneshmand, S; Gontero, P; Gonzalez, J; Haferkamp, A; Hohenfellner, M; Huang, WC; Koppie, TM; Linares, E; Lorentz, CA; Mandel, P; Martinez-Salamanca, JI; Master, VA; Matloob, R; McKiernan, JM; Mlynarczyk, CM; Montorsi, F; Novara, G; Pahernik, S; Palou, J; Pruthi, RS; Ramaswamy, K; Rodriguez Faba, O; Russo, P; Shariat, SF; Spahn, M; Terrone, C; Thieu, W; Vergho, D; Wallen, EM; Xylinas, E; Zigeuner, R; Libertino, JA; Evans, CP.
Impact of synchronous metastasis distribution on cancer specific survival in renal cell carcinoma after radical nephrectomy with tumor thrombectomy.
J Urol. 2015; 193(2):436-442
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Autor/innen der Med Uni Graz:
Chromecki Thomas
Zigeuner Richard

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Metastatic renal cell carcinoma can be clinically diverse in terms of the pattern of metastatic disease and response to treatment. We studied the impact of metastasis and location on cancer specific survival. The records of 2,017 patients with renal cell cancer and tumor thrombus who underwent radical nephrectomy and tumor thrombectomy from 1971 to 2012 at 22 centers in the United States and Europe were analyzed. Number and location of synchronous metastases were compared with respect to patient cancer specific survival. Multivariable Cox regression models were used to quantify the impact of covariates. Lymph node metastasis (155) or distant metastasis (725) was present in 880 (44%) patients. Of the patients with distant disease 385 (53%) had an isolated metastasis. The 5-year cancer specific survival was 51.3% (95% CI 48.6-53.9) for the entire group. On univariable analysis patients with isolated lymph node metastasis had a significantly worse cancer specific survival than those with a solitary distant metastasis. The location of distant metastasis did not have any significant effect on cancer specific survival. On multivariable analysis the presence of lymph node metastasis, isolated distant metastasis and multiple distant metastases were independently associated with cancer specific survival. Moreover higher tumor thrombus level, papillary histology and the use of postoperative systemic therapy were independently associated with worse cancer specific survival. In our multi-institutional series of patients with renal cell cancer who underwent radical nephrectomy and tumor thrombectomy, almost half of the patients had synchronous lymph node or distant organ metastasis. Survival was superior in patients with solitary distant metastasis compared to isolated lymph node disease. Copyright © 2015 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Aged, 80 and over -
Carcinoma, Renal Cell - mortality
Carcinoma, Renal Cell - secondary
Carcinoma, Renal Cell - surgery
Humans -
Kidney Neoplasms - mortality
Kidney Neoplasms - pathology
Kidney Neoplasms - surgery
Middle Aged -
Neoplastic Cells, Circulating -
Nephrectomy - methods
Survival Rate -
Thrombectomy -
Young Adult -

Find related publications in this database (Keywords)
renal cell
neoplasm metastasis
vena cava
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