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Lerchbaum, E.
Vitamin D and menopause--a narrative review.
Maturitas. 2014; 79(1):3-7
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Lerchbaum Elisabeth

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There is accumulating evidence that vitamin D (VD) has important effects besides its well-known role in calcium and bone metabolism. Hypovitaminosis D is associated with cardiovascular disease, the metabolic syndrome, type 2 diabetes mellitus, cancer as well as with increased mortality. Further, VD deficiency is related to depression and impaired cognitive function. Increasing age and elevated body fat mass contribute to an increased risk of VD deficiency. Further, some studies report a relationship between VD and estrogen metabolism. During menopause, the decline of estrogens results in increased bone turnover, a decrease in bone mineral density and elevated fracture risk. Musculoskeletal discomfort might impair quality of life, mood disturbances do frequently occur and the risk of metabolic and cardiovascular disease increases. Moreover, body composition changes including increased fat mass and decreased lean mass, which results in an increased risk of VD deficiency. Conversely, VD deficiency might aggravate discomfort as well as diseases that occur during menopause. There are precise recommendations regarding a sufficient VD intake in order to prevent bone loss in peri- and postmenopausal women. Considering the fact that VD deficiency and menopause share risk factors beyond bone health such as cardiovascular, metabolic, cognitive and affective disorders, a sufficient VD status should be obtained in all peri- and postmenopausal women. This might be beneficial not only considering bone health but also regarding cognitive, affective, metabolic and cardiovascular health of women. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Bone Remodeling - physiology
Cardiovascular Diseases - etiology
Female -
Humans -
Menopause - physiology
Menopause - psychology
Metabolic Diseases - etiology
Mood Disorders - etiology
Musculoskeletal Pain - etiology
Quality of Life -
Risk Factors -
Vitamin D - physiology
Vitamin D Deficiency - complications
Vitamins - physiology

Find related publications in this database (Keywords)
Vitamin D
Cardiovascular disease
Musculoskeletal disease
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