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SHR Neuro Krebs Kardio Lipid

Weger, M; Steinbrugger, I; Haas, A; März, W; El-Shabrawi, Y; Weger, W; Schmut, O; Renner, W.
Role of the interleukin-6 -174 G>C gene polymorphism in retinal artery occlusion.
STROKE. 2005; 36(2): 249-252. [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
El-Shabrawi Yosuf
Haas Anton
Maerz Winfried
Renner Wilfried
Schmut Otto
Steinbrugger Iris
Weger Martin
Weger Wolfgang
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Abstract:
BACKGROUND AND PURPOSE: Proinflammatory cytokines including interleukin-6 (IL-6) are supposed to play a pivotal role in the development of atherosclerosis. A common polymorphism in the promoter of the IL-6 gene (IL-6 -174G>C) affects plasma IL-6 concentrations and has been suggested as a risk factor for cardiovascular disease. The aim of the present case-control study was to investigate the role of this polymorphism for retinal artery occlusion (RAO). METHODS: One hundred eighty-two patients with RAO and 307 control subjects were genotyped for the IL-6 -174G>C polymorphism. Genotypes were determined by fluorogenic exonuclease (TaqMan) assay. RESULTS: The prevalence of the CC genotype was significantly lower in patients with RAO than in control subjects (10.4% versus 19.9%; P=0.006). Homozygosity for the C allele was associated with an odds ratio of 0.50 (95% CI, 0.28 to 0.89) for RAO. CONCLUSIONS: The CC genotype of the IL-6 -174G>C polymorphism may be associated with a protective effect against RAO.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Alleles -
Blood Pressure -
Case-Control Studies -
Diabetes Complications - genetics
Female - genetics
Genotype - genetics
Homozygote - genetics
Humans - genetics
Interleukin-6 - genetics
Logistic Models - genetics
Male - genetics
Middle Aged - genetics
Models, Statistical - genetics
Odds Ratio - genetics
Polymorphism, Genetic - genetics
Retinal Artery Occlusion - genetics
Retrospective Studies - genetics

Find related publications in this database (Keywords)
atherosclerosis
genetics
interleukin-6
ophthalmology
retinal artery occlusion
risk factors
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