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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Boltz, A; Told, R; Napora, KJ; Palkovits, S; Werkmeister, RM; Schmidl, D; Popa-Cherecheanu, A; Garhöfer, G; Schmetterer, L.
Optic nerve head blood flow autoregulation during changes in arterial blood pressure in healthy young subjects.
PLoS One. 2013; 8(12):e82351-e82351 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Autor/innen der Med Uni Graz:
Palkovits Stefan

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Number of Figures: 1
In the present study the response of optic nerve head blood flow to an increase in ocular perfusion pressure during isometric exercise was studied. Based on our previous studies we hypothesized that subjects with an abnormal blood flow response, defined as a decrease in blood flow of more than 10% during or after isometric exercise, could be identified. A total of 40 healthy subjects were included in this study. Three periods of isometric exercise were scheduled, each consisting of 2 minutes of handgripping. Optic nerve head blood flow was measured continuously before, during and after handgripping using laser Doppler flowmetry. Blood pressure was measured non-invasively in one-minute intervals. Intraocular pressure was measured at the beginning and the end of the measurements and ocular perfusion pressure was calculated as 2/3*mean arterial pressure -intraocular pressure. Isometric exercise was associated with an increase in ocular perfusion pressure during all handgripping periods (p < 0.001). By contrast no change in optic nerve head blood flow was seen. However, in a subgroup of three subjects blood flow showed a consistent decrease of more than 10% during isometric exercise although their blood pressure values increased. In addition, three other subjects showed a consistent decline of blood flow of more than 10% during the recovery periods. Our data confirm previous results indicating that optic nerve head blood flow is autoregulated during an increase in perfusion pressure. In addition, we observed a subgroup of 6 subjects (15%) that showed an abnormal response, which is in keeping with our previous data. The mechanisms underlying this abnormal response remain to be shown.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Blood Pressure -
Exercise -
Female -
Hemodynamics - physiology
Humans -
Intraocular Pressure -
Laser-Doppler Flowmetry -
Male -
Optic Disk - blood supply
Young Adult -

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