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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Boltz, A; Schmidl, D; Werkmeister, RM; Lasta, M; Kaya, S; Palkovits, S; Told, R; Napora, KJ; Popa-Cherecheanu, A; Garhöfer, G; Schmetterer, L.
Regulation of optic nerve head blood flow during combined changes in intraocular pressure and arterial blood pressure.
J Cereb Blood Flow Metab. 2013; 33(12):1850-1856 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Autor/innen der Med Uni Graz:
Palkovits Stefan

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Plum Analytics:
Number of Figures: 8
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In the choroid, there is evidence that blood flow does not only depend on ocular perfusion pressure (OPP), but also on absolute mean arterial pressure (MAP) and intraocular pressure (IOP). The present study included 40 healthy subjects to investigate whether such behavior is also found in the optic nerve head (ONH). The ONH blood flow (ONHBF) was studied using laser Doppler flowmetry during a separate increase in IOP and MAP as well as during a combined elevation. Mean arterial pressure was increased by isometric exercise and IOP by the suction method. During both, the change in ONHBF was less pronounced than the change in OPP indicating autoregulation. Correlation analysis was performed for the combined experiments after pooling all data according to IOP and MAP values. A correlation between ONHBF and MAP was found at IOPs 25 mm Hg (P<0.001), but not at IOPs>25 mm Hg (P=0.79). Optic nerve head blood flow and IOP were significantly correlated (P<0.001), and ONHBF was only slightly dependent on MAP. The data of the present study indicate a complex regulation of ONHBF during combined changes in MAP and IOP. Our results may be compatible with myogenic mechanisms underlying autoregulation, and indicate better ONHBF regulation during an increase in MAP than during an increase in IOP.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Arterial Pressure -
Cross-Over Studies -
Female -
Hemodynamics -
Homeostasis -
Humans -
Intraocular Pressure -
Laser-Doppler Flowmetry -
Male -
Optic Disk - blood supply
Prospective Studies -
Regional Blood Flow -
Young Adult -

Find related publications in this database (Keywords)
blood flow
laser Doppler flowmetry
ocular perfusion pressure
optic nerve head
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