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Arzt, L; Quehenberger, F; Halbwedl, I; Mairinger, T; Popper, HH.
BAP1 protein is a progression factor in malignant pleural mesothelioma.
Pathol Oncol Res. 2014; 20(1):145-151
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Arzt-Gradwohl Lisa
Halbwedl Iris
Popper Helmuth
Quehenberger Franz
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Abstract:
Human malignant pleural mesothelioma (MPM) is an aggressive cancer due to former asbestos exposure with little knowledge about prognostic factors of outcome and resistance to conventional therapy. BRCA1-associated protein 1 (BAP1) is a tumor suppressor gene that is frequently lost in MPM. Germline mutations of BAP1 predispose to several different tumors including malignant mesothelioma. Our study aimed to clarify if asbestos exposure has an influence on BAP1 expression and if BAP1 expression could be used as a prognostic factor of outcome. An immunohistochemical staining for BAP1 was performed on 123 MPM tissue samples and the expression levels have been correlated with asbestos exposure and overall survival time. BAP1 expression was not associated with asbestos exposure but we detected a significant effect of BAP1 expression on overall survival time--the higher the BAP1 expression (non-mutated BAP1), the shorter the overall survival. BAP1 mutation has been linked to non-asbestos induced familial mesotheliomas, which usually belong to the long survivor group and BAP1 is most probably functioning differently than in sporadic cases. Further investigations need to be performed to characterize the BAP1 mutations and to identify the BAP1 downstream targets in MPM.
Find related publications in this database (using NLM MeSH Indexing)
Asbestos - adverse effects
Disease Progression -
Female -
Humans -
Immunohistochemistry - methods
Lung Neoplasms - genetics
Lung Neoplasms - pathology
Male -
Mesothelioma - genetics
Mesothelioma - pathology
Mutation -
Pleural Neoplasms - genetics
Pleural Neoplasms - pathology
Prognosis -
Tumor Suppressor Proteins - genetics
Ubiquitin Thiolesterase - genetics

Find related publications in this database (Keywords)
BRCA1-associated protein1 (BAP1)
Malignant pleuralmesothelioma
Asbestos exposure
Overall survival
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