Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Keil, F; Selzer, E; Berghold, A; Reinisch, S; Kapp, KS; De Vries, A; Greil, R; Bachtiary, B; Tinchon, C; Anderhuber, W; Burian, M; Kasparek, AK; Elsäßer, W; Kainz, H; Riedl, R; Kopp, M; Kornek, G.
Induction chemotherapy with docetaxel, cisplatin and 5-fluorouracil followed by radiotherapy with cetuximab for locally advanced squamous cell carcinoma of the head and neck.
Eur J Cancer. 2013; 49(2):352-359
Doi: 10.1016/j.ejca.2012.08.004
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Anderhuber Wolfgang
- Berghold Andrea
- Kapp Karin S.
- Kasparek Anne-Katrin
- Reinisch Sabine
- Riedl Regina
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- Abstract:
- Purpose: To determine the efficacy and feasibility of induction chemotherapy (ICT) with docetaxel, cisplatin and 5-fluorouracil followed by radiotherapy and cetuximab (C) in patients with locally advanced head and neck cancer. Patients and methods: Forty-nine previously untreated patients with local advanced stage III and IV squamous cell carcinoma of the head and neck (SCCHN) received three courses of ICT consisting of docetaxel 75 mg/m(2) day 1, cisplatin 75 mg/m(2) day 1 and infusional 5-fluorouracil 750 mg/m(2)/day on days 1-5 followed by radiotherapy plus C at 250 mg/m(2)/week (after an initial loading dose of 400 mg/m(2)). Results: After completion of ICT 44 of 49 patients received radiotherapy plus C. Three months after therapy completion tumour response was observed in 33 patients and after two years, 25 patients were in complete remission (CR). The most common grade 4 toxicity during the whole treatment period was dermatitis (30%), followed by mucositis (27%) and neutropenia (17%) without fever. One toxic related death was observed during ICT. Two-year progression-free survival (PFS) rate was 59% and two-year overall survival (OS) rate was 63%, respectively. Conclusion: Concurrent radiotherapy plus C after three courses of ICT was feasible and was associated with promising CR, PFS and OS rates. Further optimisation of dose and sequence is warranted. (C) 2012 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - adverse effects
- Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use
- Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - radiotherapy
- Cisplatin - administration & dosage Cisplatin - adverse effects
- Disease-Free Survival -
- Female -
- Fluorouracil - administration & dosage Fluorouracil - adverse effects
- Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - pathology Head and Neck Neoplasms - radiotherapy
- Humans -
- Induction Chemotherapy -
- Male -
- Middle Aged -
- Taxoids - administration & dosage Taxoids - adverse effects
- Find related publications in this database (Keywords)
- SSCHN
- Induction chemotherapy
- Radiotherapy
- Cetuximab