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Gewählte Publikation:

Kleinert, R.
Immunohistochemical characterization of primitive neuroectodermal tumors and their possible relationship to the stepwise ontogenetic development of the central nervous system. 2. Tumor studies.
Acta Neuropathol (Berl). 1991; 82(6):508-515
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Autor/innen der Med Uni Graz:
Kleinert Reinhold

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Thirty-five selected intracranial tumors qualifying as primitive neuroectodermal tumors (PNETs) were investigated; these included medulloblastomas, cerebral neuroblastomas, pinealoblastomas, retinoblastomas, polar spongioblastomas, ependymoblastomas. For control purposes 11 tumors, including glioblastomas (small cell, spongioblastic variants), one anaplastic astrocytoma (astroblastic component), anaplastic oligo-astrocytomas, gangliogliomas, one primary melanoblastoma, and one pineal germinoma, were also studied. Six neuronal markers, i.e., synaptophysin, chromogranin A, neuron-specific enolase (NSE), neurofilament protein (NFP) (160 kDa, 200 kDa, 70 and 200 kDa), and six other markers (glial fibrillary acidic protein, S-100 protein, vimentin, myoglobin, desmin, cytokeratin) were investigated immunohistochemically. A certain recapitulation of the ontogenetic development of neuronal differentiation in PNETs is given by the fact that chromogranin A immunoreactivity can regularly be seen already in poorly differentiated neurons and synaptophysin in well-differentiated ones. Immunostaining for NFPs showed different results depending on the subunit investigated. NSE reaction gave different results even within the single tumor groups. This study is, to the best of our knowledge, the first attempt to evaluate and compare, by combined morphological and immunohistochemical methods, PNETs without and with different stages of cellular differentiation with the stepwise differentiation of the human embryonic neuroectoderm.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Brain Neoplasms - metabolism
Central Nervous System - embryology
Child - embryology
Child, Preschool - embryology
Embryonic and Fetal Development - embryology
Female - embryology
Humans - embryology
Immunohistochemistry - embryology
Infant - embryology
Infant, Newborn - embryology
Male - embryology
Middle Aged - embryology
Neoplasms, Germ Cell and Embryonal - metabolism

Find related publications in this database (Keywords)
Primitive Neuroectodermal Tumors (Pnet)
Cellular Differentiation
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