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Yasmin, N; Konradi, S; Eisenwort, G; Schichl, YM; Seyerl, M; Bauer, T; Stöckl, J; Strobl, H.
β-Catenin promotes the differentiation of epidermal Langerhans dendritic cells.
J Invest Dermatol. 2013; 133(5):1250-1259 [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Bauer Thomas
Strobl Herbert
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Abstract:
The epithelial signaling protein and transcriptional regulator β-catenin has recently been implicated in hematopoietic dendritic cell (DC) differentiation as well as in DC-mediated tolerance. We here observed that epidermal Langerhans cells (LCs) but not interstitial/dermal DCs express detectable β-catenin. LCs are unique among the DC family members in that LC networks critically depend on epithelial adhesion molecules as well as on the cytokine transforming growth factor-β1 (TGF-β1). However, despite the important functions of LCs in the immune system, the molecular mechanisms governing LC differentiation and maintenance remain poorly defined. We found that TGF-β1 induces β-catenin in progenitor cells undergoing LC differentiation and that β-catenin promotes LC differentiation. Vitamin D, another epidermal signal, enhanced TGF-β1-mediated β-catenin induction and promoted the expression of multiple epithelial genes by LCs. Moreover, full-length vitamin D receptor (VDR) promoted, whereas a truncated VDR diminished, the positive effects of ectopic β-catenin on LC differentiation. Therefore, we here identified β-catenin as a positive regulator of LC differentiation in response to TGF-β1 and identified a functional interaction between β-catenin and VDR in these cells.
Find related publications in this database (using NLM MeSH Indexing)
Cadherins - metabolism
Cell Differentiation - drug effects
Cells, Cultured -
Epidermis - cytology
Hematopoietic Stem Cells - cytology
Humans -
Langerhans Cells - cytology
Receptors, Calcitriol - metabolism
Signal Transduction - physiology
Transforming Growth Factor beta1 - pharmacology
Vitamin D - pharmacology
beta Catenin - metabolism

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