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SHR Neuro Krebs Kardio Lipid

Esmaeelpour, M; Brunner, S; Ansari-Shahrezaei, S; Shahrezaei, SA; Nemetz, S; Povazay, B; Kajic, V; Drexler, W; Binder, S.
Choroidal thinning in diabetes type 1 detected by 3-dimensional 1060 nm optical coherence tomography.
Invest Ophthalmol Vis Sci. 2012; 53(11):6803-6809 [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Ansari Shahrezaei Siamak

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Plum Analytics:
To map choroidal (ChT) and retinal thickness (RT) in patients with diabetes type 1 with and without maculopathy and retinopathy in order to compare them with healthy subjects using high speed 3-dimensional (3D) 1060 nm optical coherence tomography (OCT). Thirty-three eyes from 33 diabetes type 1 subjects (23-57 years, 15 male) divided into groups of without pathology (NDR) and with pathology (DR; including microaneurysms, exudates, clinically significant macular-oedema and proliferative retinopathy) were compared with 20 healthy axial eye length and age-matched subjects (24-57 years, 9 male), imaged by high speed (60.000 A-scans/s) 3D 1060 nm OCT performed over 36° × 36° field of view. Ocular health status, disease duration, body mass index, haemoglobin-A1c, and blood pressure (bp) measurements were recorded. Subfoveal ChT, and 2D topographic maps between retinal pigment epithelium and the choroidal/scleral-interface, were automatically generated and statistically analyzed. Subfoveal ChT (mean ± SD, μm) for healthy eyes was 388 ± 109; significantly thicker than all diabetic groups, 291 ± 64 for NDR, and 303 ± 82 for DR (ANOVA P < 0.004, Tukey P = 0.01 for NDR and DR). Thinning did not relate to recorded factors (multi-regression analysis, P > 0.05). Compared with healthy eyes and the NDR, the averaged DR ChT-map demonstrated temporal thinning that extended superiorly and temporal-inferiorly (unpaired t-test, P < 0.05). Foveal RT and RT-maps showed no statistically significant difference between groups (mean SD, μm, healthy 212 ± 17, NDR 217 ± 15, DR 216 ± 27, ANOVA P > 0.05). ChT is decreased in diabetes type 1, independent of the absence of pathology and of diabetic disease duration. In eyes with pathology, 3D 1060 nm OCT averaged maps showed an extension of the thinning area matching retinal lesions and suggesting its involvement on onset or progression of disease.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Choroid - pathology
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - pathology
Diabetic Retinopathy - etiology
Diabetic Retinopathy - pathology
Diagnosis, Differential -
Female -
Humans -
Imaging, Three-Dimensional -
Male -
Middle Aged -
Reproducibility of Results -
Tomography, Optical Coherence - methods
Young Adult -

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