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Langkammer, C; Liu, T; Khalil, M; Enzinger, C; Jehna, M; Fuchs, S; Fazekas, F; Wang, Y; Ropele, S.
Quantitative susceptibility mapping in multiple sclerosis.
Radiology. 2013; 267(2):551-559 Doi: 10.1148/radiol.12120707 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Langkammer Christian
Co-Autor*innen der Med Uni Graz
Enzinger Christian
Fazekas Franz
Fuchs Siegrid
Jehna Margit
Khalil Michael
Ropele Stefan

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To apply quantitative susceptibility mapping (QSM) in the basal ganglia of patients with multiple sclerosis (MS) and relate the findings to R2* mapping with regard to the sensitivity for clinical and morphologic measures of disease severity. The local ethics committee approved this study, and all subjects gave written informed consent. Sixty-eight patients (26 with clinically isolated syndrome, 42 with relapsing-remitting MS) and 23 control subjects underwent 3-T magnetic resonance (MR) imaging. Susceptibility and R2* maps were reconstructed from the same three-dimensional multiecho spoiled gradient-echo sequence. Mean susceptibilities and R2* rates were measured in the basal ganglia and were compared between different phenotypes of the disease (clinically isolated syndrome, MS) and the control subjects by using analysis of variance, and regressing analysis was used to identify independent predictors. Compared with control subjects, patients with MS and clinically isolated syndrome had increased (more paramagnetic) magnetic susceptibilities in the basal ganglia. R2* mapping proved less sensitive than QSM regarding group differences. The strongest predictor of magnetic susceptibility was age. Susceptibilities were higher with increasing neurologic deficits (r = 0.34, P < .01) and lower with normalized volumes of gray matter (r = -0.35, P < .005) and the cortex (r = -0.35, P < .005). QSM provides superior sensitivity over R2* mapping in the detection of MS-related tissue changes in the basal ganglia. With QSM but not with R2* mapping, changes were already observed in patients with clinically isolated syndrome, which suggests that QSM can serve as a sensitive measure at the earliest stage of the disease. © RSNA, 2013.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Analysis of Variance -
Basal Ganglia - pathology
Female -
Humans -
Magnetic Resonance Imaging - methods
Male -
Middle Aged -
Multiple Sclerosis - pathology
Multiple Sclerosis, Relapsing-Remitting - pathology
Phenotype -
Prospective Studies -
Regression Analysis -
Sensitivity and Specificity -
Severity of Illness Index -
Statistics, Nonparametric -

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