Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Okada, Y; Sim, X; Go, MJ; Wu, JY; Gu, D; Takeuchi, F; Takahashi, A; Maeda, S; Tsunoda, T; Chen, P; Lim, SC; Wong, TY; Liu, J; Young, TL; Aung, T; Seielstad, M; Teo, YY; Kim, YJ; Lee, JY; Han, BG; Kang, D; Chen, CH; Tsai, FJ; Chang, LC; Fann, SJ; Mei, H; Rao, DC; Hixson, JE; Chen, S; Katsuya, T; Isono, M; Ogihara, T; Chambers, JC; Zhang, W; Kooner, JS; KidneyGen Consortium; CKDGen Consortium; Albrecht, E; GUGC consortium; Yamamoto, K; Kubo, M; Nakamura, Y; Kamatani, N; Kato, N; He, J; Chen, YT; Cho, YS; Tai, ES; Tanaka, T.
Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
Nat Genet. 2012; 44(8):904-909 Doi: 10.1038/ng.2352 [OPEN ACCESS]
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Study Group Mitglieder der Med Uni Graz:
Schallert Michael
Schmidt Helena
Schmidt Reinhold

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Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10(-8)). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.
Find related publications in this database (using NLM MeSH Indexing)
Asian Continental Ancestry Group - genetics
Blood Urea Nitrogen -
Cohort Studies -
Creatinine - blood
Genetic Predisposition to Disease -
Genome-Wide Association Study -
Glomerular Filtration Rate - genetics
Humans -
Kidney - physiology
Polymorphism, Single Nucleotide -
Renal Insufficiency, Chronic - genetics
Uric Acid - blood

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