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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Hoenigl, M; Krause, R.
Antifungal therapy of aspergillosis of the central nervous system and aspergillus endophthalmitis.
Curr Pharm Des. 2013; 19(20):3648-3668
Web of Science PubMed

 

Autor/innen der Med Uni Graz:
Hönigl Martin
Krause Robert
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Abstract:
Cerebral Aspergillosis is the most lethal manifestation of infection due to Aspergillus species arising most commonly as hematogenous dissemination from a pulmonary focus, direct extension from paranasal sinus infection or direct inoculation through trauma and surgery of the central nervous system (CNS). Voriconazole is currently considered the standard of treatment of CNS aspergillosis with liposomal amphotericin B being the next best alternative. Neurosurgical resection of infected cerebral tissue in addition to antifungal therapy is frequently performed in patients with CNS aspergillosis to prevent neurological deficits and improve outcome. Aspergillus endophthalmitis may occur endogenously mostly from a pulmonary focus or exogenously following eye surgery or trauma. Although amphotericin B is still described as the primary therapy, voriconazole is increasingly considered the first line treatment of Aspergillus endophthalmitis. Vitrectomy is recommended in most cases of Aspergillus endophthalmitis.
Find related publications in this database (using NLM MeSH Indexing)
Amphotericin B - therapeutic use
Animals -
Antifungal Agents - therapeutic use
Aspergillosis - drug therapy
Aspergillus - isolation & purification
Combined Modality Therapy -
Endophthalmitis - drug therapy
Eye Infections, Fungal - drug therapy
Humans -
Neuroaspergillosis - drug therapy
Pyrimidines - therapeutic use
Triazoles - therapeutic use
Vitrectomy - methods

Find related publications in this database (Keywords)
Aspergillus
invasive aspergillosis
endophthalmitis
central nervous system
CNS infection
blood brain barrier
CSF levels
tissue levels
voriconazole
posaconazole
amphotericin B
liposomal amphotericin B
echinocandin
itraconazole
epidemiology
surgery
surgical
neurosurgical
vitrectomy
intravitreal
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