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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Steinicke, R; Gaertner, B; Grittner, U; Schmidt, W; Dichgans, M; Heuschmann, PU; Tanislav, C; Putaala, J; Kaps, M; Endres, M; Schmidt, R; Fazekas, F; Norrving, B; Rolfs, A; Martus, P; Tatlisumak, T; Enzinger, C; Jungehulsing, GJ.
Kidney Function and White Matter Disease in Young Stroke Patients: Analysis of the Stroke in Young Fabry Patients Study Population.
Stroke. 2012; 43(9):2382-2388 Doi: 10.1161/STROKEAHA.111.645713 [OPEN ACCESS]
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Co-Autor*innen der Med Uni Graz
Enzinger Christian
Fazekas Franz
Schmidt Reinhold

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Background and Purpose-Impaired kidney function is thought to be associated with small vessel disease, outcome, and mortality in the general stroke population. Data are limited regarding young patients. The aim of this study was to investigate the association of kidney function and white matter hyperintensities (WMHs) in young patients with first ischemic stroke. Methods-We analyzed 2500 young (18-55 years) patients with first-ever ischemic stroke from the prospective observational Stroke in Young Fabry Patients (SIFAP1) study with available MRI data on WMH. Of these, 2009 had available data concerning estimated glomerular filtration rate (eGFR). Kidney function was expressed as eGFR by the Modification of Diet in Renal Disease method. Deep WMHs on MRI were classified by the Fazekas score. Multivariate analysis was performed using a regression model with random effects. Results-Mean eGFR was 96.7 mL/min in those with WMH Grade 0 to 1 (none to mild), 90.7 mL/min in WMH Grade 2 (moderate), and 89 mL/min in WMH Grade 3 (severe). Univariate analysis revealed WMH to be associated with age (P<0.001), hypertension (P<0.001), cardiovascular disease (P=0.015), overweight (body mass index >25 kg/m(2); P=0.013), current smoking (P=0.044), and eGFR (P=0.009). In multivariate analysis, age, hypertension, and eGFR remained associated with WMH severity. Conclusions-In young patients with acute ischemic stroke, lower eGFR values in the normal range are associated with the presence of moderate to severe WMH.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Brain Diseases - etiology
Brain Ischemia - complications
Cohort Studies -
Cross-Sectional Studies -
Female -
Glomerular Filtration Rate - physiology
Humans -
Image Processing, Computer-Assisted -
Kidney - physiopathology
Kidney Function Tests -
Logistic Models -
Magnetic Resonance Imaging -
Male -
Middle Aged -
Multivariate Analysis -
Risk Factors -
Stroke - complications
Vascular Diseases - pathology
Young Adult -

Find related publications in this database (Keywords)
estimated glomerular filtration rate (eGFR) kidney function
white matter hyperintensities (WMH)
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