Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Füchtner, F; Angelberger, P; Kvaternik, H; Hammerschmidt, F; Simovc, BP; Steinbach, J.
Aspects of 6-[18F]fluoro-L-DOPA preparation: precursor synthesis, preparative HPLC purification and determination of radiochemical purity.
Nucl Med Biol. 2002; 29(4):477-481
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Autor/innen der Med Uni Graz:
Kvaternik Herbert
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Abstract:
A modified method for the synthesis of the intermediate product N-Boc-3,4-di(Boc-O)-6-iodo-L-phenylalanine ethyl ester of the [18F]FDOPA precursor preparation was developed. With the application of bis-(trifluoroacetoxy)-iodobenzene for the iodination step with elemental iodine the yield of the intermediate can be increased from 12% to 50-60%. By replacing silica-gel-based RP HPLC column by a polymer-based column for semi-preparative purification of [18F]FDOPA from the reaction mixture the radiochemical purity of the final product can be increased up to >99%. For the determination of the radiochemical impurity [18F]fluoride a HPLC method using a column with polymer-based RP material was introduced.
Find related publications in this database (using NLM MeSH Indexing)
Chromatography, High Pressure Liquid -
Dihydroxyphenylalanine - analogs and derivatives Dihydroxyphenylalanine - chemical synthesis Dihydroxyphenylalanine - isolation and purification
Models, Chemical -
Quality Control -
Radiopharmaceuticals - chemical synthesis Radiopharmaceuticals - isolation and purification
Sensitivity and Specificity -

Find related publications in this database (Keywords)
18F
FDOPA preparation
FDOPA quality control
PET
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