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Gewählte Publikation:

Hinghofer-Szalkay, HG; Vigas, M; Sauseng-Fellegger, G; König, EM; Lichardus, B; Jezová, D.
Head-up tilt and lower body suction: comparison of hormone responses in healthy men.
Physiol Res. 1996; 45(5):369-378
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Autor/innen der Med Uni Graz:
Hinghofer-Szalkay Helmut
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Abstract:
The purpose of this study was to compare, in the same subjects, hormonal responses to 30-min head-up tilt (HUT) and lower body suction (LBNP) of different intensity (24 degrees and 70 degrees, and 15 and 35 mm Hg, respectively). Basal pooled individual data from -10 min (n = 32) were within normal reference limits: norepinephrine (NE) averaged 318 +/- 23 pg/ml; epinephrine, 34.0 +/- 5.5 pg/ml; plasma renin activity (PRA), 0.72 +/- 0.08 ng ATII/ml/h; aldosterone, 164 +/- 20 pg/ml; atrial natriuretic peptide (ANP), 29.9 +/- 2.0 pg/ml; cGMP, 6.29 +/- 0.59 mmol/l; cortisol, 95.7 +/- 5.8 ng/ml; and ACTH, 50.3 +/- 2.6 pg/ml. The low-level stimuli failed to induce consistent changes in hormone levels. From the onset of the stimulus (minute 0) to its termination (minute 30), norepinephrine (NE) increased by 101% with LBNP-35, and by 70% with HUT70, respectively. The NE increase with LBNP-35 was higher (p < 0.05) than with HUT70. Epinephrine rose with HUT70 (by 162%) only. PRA increased by 157% with LBNP-35, and by 119% with HUT70, respectively; these responses were not significantly different. Aldosterone rose equally (by 85 and 89%) with LBNP-35 and HUT70 but not with the low-level stimuli. No consistent changes were observed in ANP, c-GMP or ACTH concentrations. Cortisol values fell during the LBNP and HUT24 situations but rose transiently after HUT70. We conclude that the hormones investigated respond differently to head-up posture and lower body suction and in a specific manner. Greater effects of high-level stimuli (HUT70, LBNP-35) were noted as compared to low-level stimuli (HUT24, LBNP-15). The application of combined sets of models stimulating the cardiovascular system may aid in the analysis of responses of hormonal systems in man.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Blood Pressure - physiology
Heart Rate - physiology
Hormones - blood
Humans - blood
Lower Body Negative Pressure - blood
Male - blood
Posture - physiology
Time Factors - physiology

Find related publications in this database (Keywords)
Simulated Orthostasis
Cardiovascular Stimulus
Catecholamines
Volume-Regulating and Stress Dependent Hormones
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