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SHR Neuro Krebs Kardio Lipid

Thieme, D; Peschel, O; Fischer, F; Graw, M.
Multi target analysis of putrefactive specimens by liquid chromatography-tandem mass spectrometry to prove multiple poisonings by hypnotics and muscle relaxants.
Drug Test Anal. 2009; 1(4):156-161
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Autor/innen der Med Uni Graz:
Fischer Florian Tobias

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The muscle relaxant rocuronium and the hypnotics etomidate, diazepam and midazolam were candidate poisons in a case of a suspected series of fatal intoxications in a hospital. A robust, specific and sensitive multi-target screening procedure was established to identify unequivocally the parent compounds and diagnostic metabolites and artefacts in putrefied specimens, obtained from exhumed bodies. The analytical findings of relevant compounds could be traced partially back to authorised therapeutic measures, whereas the identification of rocuronium proved potentially lethal intoxications in 13 (of a total number of 42) cases. Moreover, the detection of certain hypnotics revealed an improper administration of these compounds in another nine cases, which suggested manipulation but was not indicative of fatal intoxications. Quantitative estimations of substance concentrations were highly correlated with the post-mortem time intervals and did not reveal any information on doses, initial serum concentrations or toxicological effects.
Find related publications in this database (using NLM MeSH Indexing)
Androstanols - pharmacokinetics Androstanols - poisoning
Autopsy - methods
Chromatography, High Pressure Liquid - methods
Diazepam - pharmacokinetics Diazepam - poisoning
Etomidate - pharmacokinetics Etomidate - poisoning
Exhumation -
Hospitals -
Humans -
Hypnotics and Sedatives - pharmacokinetics Hypnotics and Sedatives - poisoning
Midazolam - pharmacokinetics Midazolam - poisoning
Neuromuscular Nondepolarizing Agents - pharmacokinetics Neuromuscular Nondepolarizing Agents - poisoning
Tandem Mass Spectrometry - methods
Toxicology - methods

Find related publications in this database (Keywords)
liquid chromatography-mass spectrometry
multi-target analyses
muscle relaxants
post mortem toxicology
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