Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wiltgen, M; Tilz, GP.
Molecular diagnosis and prognosis with DNA microarrays.
Hematology. 2011; 16(3):166-176
Doi: 10.1179/102453311X12953015767257
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Wiltgen Marco
- Co-Autor*innen der Med Uni Graz
- Tilz Gernot
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- Abstract:
- Microarray analysis makes it possible to determine thousands of gene expression values simultaneously. Changes in gene expression, as a response to diseases, can be detected allowing a better understanding and differentiation of diseases at a molecular level. By comparing different kinds of tissue, for example healthy tissue and cancer tissue, the microarray analysis indicates induced gene activity, repressed gene activity or when there is no change in the gene activity level. Fundamental patterns in gene expression are extracted by several clustering and machine learning algorithms. Certain kinds of cancer can be divided into subtypes, with different clinical outcomes, by their specific gene expression patterns. This enables a better diagnosis and tailoring of individual patient treatments.
- Find related publications in this database (using NLM MeSH Indexing)
- Cluster Analysis -
- Gene Expression Profiling -
- Gene Expression Regulation, Neoplastic -
- Humans -
- Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis
- Leukemia, Lymphocytic, Chronic, B-Cell - genetics
- Leukemia, Myeloid, Acute - diagnosis
- Leukemia, Myeloid, Acute - genetics
- Leukemia, Promyelocytic, Acute - diagnosis
- Leukemia, Promyelocytic, Acute - genetics
- Lymphoma, Large B-Cell, Diffuse - diagnosis
- Lymphoma, Large B-Cell, Diffuse - genetics
- Molecular Diagnostic Techniques - methods
- Oligonucleotide Array Sequence Analysis - methods
- Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - diagnosis
- Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics
- Prognosis -
- Reproducibility of Results -
- Sensitivity and Specificity -
- Survival Analysis -
- Find related publications in this database (Keywords)
- DNA microarray
- Bioinformatics
- Support vector machine
- Diffuse large B-cell lymphoma
- Acute myelogenous leukaemia
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- T-cell acute lymphoblastic leukaemia