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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Wiltgen, M; Tilz, GP.
Molecular diagnosis and prognosis with DNA microarrays.
Hematology. 2011; 16(3):166-176 Doi: 10.1179/102453311X12953015767257
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Führende Autor*innen der Med Uni Graz
Wiltgen Marco
Co-Autor*innen der Med Uni Graz
Tilz Gernot

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Microarray analysis makes it possible to determine thousands of gene expression values simultaneously. Changes in gene expression, as a response to diseases, can be detected allowing a better understanding and differentiation of diseases at a molecular level. By comparing different kinds of tissue, for example healthy tissue and cancer tissue, the microarray analysis indicates induced gene activity, repressed gene activity or when there is no change in the gene activity level. Fundamental patterns in gene expression are extracted by several clustering and machine learning algorithms. Certain kinds of cancer can be divided into subtypes, with different clinical outcomes, by their specific gene expression patterns. This enables a better diagnosis and tailoring of individual patient treatments.
Find related publications in this database (using NLM MeSH Indexing)
Cluster Analysis -
Gene Expression Profiling -
Gene Expression Regulation, Neoplastic -
Humans -
Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
Leukemia, Myeloid, Acute - diagnosis
Leukemia, Myeloid, Acute - genetics
Leukemia, Promyelocytic, Acute - diagnosis
Leukemia, Promyelocytic, Acute - genetics
Lymphoma, Large B-Cell, Diffuse - diagnosis
Lymphoma, Large B-Cell, Diffuse - genetics
Molecular Diagnostic Techniques - methods
Oligonucleotide Array Sequence Analysis - methods
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - diagnosis
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics
Prognosis -
Reproducibility of Results -
Sensitivity and Specificity -
Survival Analysis -

Find related publications in this database (Keywords)
DNA microarray
Support vector machine
Diffuse large B-cell lymphoma
Acute myelogenous leukaemia
Lymphocytic leukaemia
Acute promyelocytic leukaemia
T-cell acute lymphoblastic leukaemia
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