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SHR Neuro Krebs Kardio Lipid

Luschnig-Schratl, P; Sturm, EM; Konya, V; Philipose, S; Marsche, G; Fröhlich, E; Samberger, C; Lang-Loidolt, D; Gattenlöhner, S; Lippe, IT; Peskar, BA; Schuligoi, R; Heinemann, A.
EP4 receptor stimulation down-regulates human eosinophil function.
Cell Mol Life Sci. 2011; 68(21): 3573-3587. [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Fröhlich Eleonore
Gattenlöhner Stefan
Heinemann Akos
Konya Viktoria
Lang-Loidolt Doris
Lippe Irmgard Theresia
Luschnig Petra
Marsche Gunther
Meindl Claudia
Peskar Bernhard
Philipose Sonia
Schuligoi Rufina
Sturm Eva
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Abstract:
Accumulation of eosinophils in tissue is a hallmark of allergic inflammation. Here we observed that a selective agonist of the PGE(2) receptor EP4, ONO AE1-329, potently attenuated the chemotaxis of human peripheral blood eosinophils, upregulation of the adhesion molecule CD11b and the production of reactive oxygen species. These effects were accompanied by the inhibition of cytoskeletal rearrangement and Ca(2+) mobilization. The involvement of the EP4 receptor was substantiated by a selective EP4 antagonist, which reversed the inhibitory effects of PGE(2) and the EP4 agonist. Selective kinase inhibitors revealed that the inhibitory effect of EP4 stimulation on eosinophil migration depended upon activation of PI 3-kinase and PKC, but not cAMP. Finally, we found that EP4 receptors are expressed by human eosinophils, and are also present on infiltrating leukocytes in inflamed human nasal mucosa. These data indicate that EP4 agonists might be a novel therapeutic option in eosinophilic diseases.
Find related publications in this database (using NLM MeSH Indexing)
Antigens, CD11b - metabolism
Calcium - metabolism
Calcium Channels - chemistry
Cell Movement -
Cyclopentanes - pharmacology
Dinoprostone - pharmacology
Down-Regulation -
Eosinophils - drug effects
Humans -
Inflammation - metabolism
Isoindoles - pharmacology
Nasal Mucosa - metabolism
Phosphatidylinositol 3-Kinases - metabolism
Protein Kinase C - metabolism
Protein Kinase Inhibitors - pharmacology
Reactive Oxygen Species - metabolism
Receptors, Prostaglandin E, EP4 Subtype - agonists
Sulfonamides - pharmacology
Thioglycolates - pharmacology

Find related publications in this database (Keywords)
Eosinophils
Prostaglandins
Receptors
Chemotaxis
Reactive oxygen species
Degranulation
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