Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Theegarten, D; Albrecht, S; Tötsch, M; Teschler, H; Neubauer, H; Al Dahouk, S.
Brucellosis of the lung: case report and review of the literature.
Virchows Arch. 2008; 452(1):97-101
Doi: 10.1007/s00428-007-0518-0
(- Case Report)
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Tötsch Martin
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- Abstract:
- Human brucellosis is a worldwide re-emerging zoonosis. However, its histological appearance has only been occasionally described. We report the case of a young girl who had been suffering from a spontaneous fracture of the eighth thoracic vertebra at the age of 7. At the age of 15, X-ray showed a translucence of the seventh and ninth thoracic vertebra, and additionally, a bi-lateral episcleritis was detected. Three months later, she was admitted to the hospital because of perspiration at night and moderate fever. Computer tomography revealed coarsely spotted infiltrates in the lower fields of both lungs. Serology for rheumatic diseases was negative. Thoracoscopical wedge resection was done for histological clarification of pulmonary changes. Microscopically, a granulomatous inflammation with central necrosis was seen. A Ziehl-Neelsen stain did not demonstrate acid-fast bacteria. In spite of negative serology, real-time polymerase chain reaction detected Brucella melitensis deoxyribonucleic acid in the formalin-fixed tissue samples of the lung. Interrogation of the patient revealed visits in different Arabian countries during childhood as a presumable source of infection. In conclusion, granulomatous inflammation negative for Ziehl-Neelsen and Grocott stains presenting together with other localized lesions should lead to specific investigations on brucellosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Animals -
- Anti-Bacterial Agents - therapeutic use
- Brucella melitensis - genetics Brucella melitensis - isolation and purification
- Brucellosis - drug therapy Brucellosis - microbiology Brucellosis - pathology
- Cattle -
- DNA, Bacterial - analysis
- Diagnosis, Differential -
- Doxycycline - therapeutic use
- Drug Therapy, Combination -
- Female -
- Humans -
- Lung Diseases - drug therapy Lung Diseases - microbiology Lung Diseases - pathology
- Magnetic Resonance Imaging -
- Prednisone - therapeutic use
- Radiography, Thoracic -
- Rifampin - therapeutic use
- Treatment Outcome -
- Find related publications in this database (Keywords)
- brucellosis
- lung
- granulomatosis
- zoonosis